Abstract
The recent observation that urinary calcium excretion (UCE) drops considerably with CKD and that this effect may occur beyond compensation for reduced intestinal calcium absorption suggests that CKD per se is a state of sustained positive calcium balance, a mechanism likely to contribute to vascular calcification and CVD in CKD. However, the determinants of UCE reduction in CKD are not well understood and there is a lack of clinical studies, particularly in the CKD population. Therefore, in this study, we aimed to evaluate variables associated with UCE in a CKD cohort. Baseline data on 356 participants of the Progredir Study, Sao Paulo, Brazil, essentially composed of CKD G3a-G4, were analyzed according to UCE (24 h urine collection). Median 24 h UCE was 38 mg/day (IQR 21-68 mg/day) and 0.48 mg/kg/day (IQR 0.28-0.82 mg/kg/day). In univariate analysis, UCE was inversely related to age, phosphorus, 1-84 PTH, FGF-23 and sclerostin, and positively associated with eGFR, DBP, 1,25(OH)2-vitamin D, calcium, bicarbonate, total calorie intake and spironolactone use. After adjustments for age, sex and eGFR, only 1,25(OH)2-vitamin D, calcium, FGF-23, bicarbonate and total calorie intake remained associated with it, but not PTH nor sclerost...Continue Reading
References
Mar 1, 1976·The Journal of Clinical Endocrinology and Metabolism·R A KaplanC Y Pak
Apr 1, 1973·Kidney International·J W CoburnS G Massry
Oct 20, 2001·Hypertension·J BlacherG M London
Apr 23, 2002·Journal of Cellular Biochemistry·Jan O GordeladzeJanne E Reseland
Sep 3, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Joost G J HoenderopRené J M Bindels
Oct 22, 2003·Journal of the American Society of Nephrology : JASN·Tom NijenhuisRené J M Bindels
Sep 17, 2005·Kidney International·Monique van AbelRené J M Bindels
Jan 25, 2006·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Daniel CoyneStuart M Sprague
Mar 7, 2006·Kidney International·T T LambersJ G J Hoenderop
Apr 12, 2008·Diabetes & Metabolism·Z A MassyS Kamel
May 6, 2009·Annals of Internal Medicine·Andrew S LeveyUNKNOWN CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration)
Oct 13, 2009·Clinical Journal of the American Society of Nephrology : CJASN·Eric N Taylor, Gary C Curhan
Dec 8, 2009·Clinical Journal of the American Society of Nephrology : CJASN·Rodrigo B OliveiraRosa M A Moysés
Mar 5, 2010·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Kiyomi TsujiNoboru Horiuchi
Dec 1, 2010·Journal of the American Society of Nephrology : JASN·Ming Chang HuOrson W Moe
Mar 9, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Tamara IsakovaUNKNOWN Chronic Renal Insufficiency Cohort (CRIC) Study Group
Apr 1, 2011·Kidney International·Domenico RussoBernadette Scognamiglio
Jan 6, 2012·Kidney International·Osamu AsaiYoshihiko Saito
Feb 3, 2012·Kidney International·David M Spiegel, Kate Brady
Dec 21, 2012·Kidney International·Kathleen M HillMunro Peacock
Mar 27, 2013·Proceedings of the National Academy of Sciences of the United States of America·Zachary C RyanRajiv Kumar
May 31, 2014·Journal of the American Society of Nephrology : JASN·Rajiv Kumar, Volker Vallon
Oct 8, 2014·Clinical Journal of the American Society of Nephrology : CJASN·Judith BlaineMoshe Levi
Jan 6, 2015·Experimental Physiology·Orly KladnitskyIsrael Zelikovic
Oct 16, 2015·PloS One·Lorena Ortega MorenoClaudia Menzaghi
May 28, 2016·American Journal of Nephrology·Raquel F V VascoRosilene M Elias
Jul 3, 2016·Kidney International·Nasser A DhayatDaniel G Fuster
Sep 1, 2016·Bone·Sharon M Moe
Oct 4, 2016·Nutrition·Young Youl HyunUNKNOWN Representing KNOW-CKD Study Group
Dec 5, 2016·Kidney International·Joseph M RutkowskiPhilipp E Scherer
Mar 23, 2017·The Journal of Clinical Endocrinology and Metabolism·Deborah M MitchellSherri-Ann M Burnett-Bowie
Apr 27, 2017·São Paulo Medical Journal = Revista Paulista De Medicina·Maria Alice Muniz DomingosSilvia Maria de Oliveira Titan
Jan 6, 2018·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Belinda SpotoCarmine Zoccali