PMID: 9191113Jun 1, 1997Paper

Calcium- and calmodulin-dependent phosphorylation of AMPA type glutamate receptor subunits by endogenous protein kinases in the post-synaptic density

Brain Research. Molecular Brain Research
Y HayashiT Takahashi

Abstract

We have detected immunoreactivities of AMPA receptor subunits GluR1-4 in post-synaptic density (PSD) fraction and tested whether they can be phosphorylated by endogenous kinases. Incubation of PSD with Ca2+ and calmodulin increased phosphorylation of GluR1 and GluR2/3. The phosphorylation of GluR1 was largely blocked by a Ca2+/calmodulin-dependent protein kinase type II inhibitor. Thus Ca2+/calmodulin-dependent phosphorylation of glutamate receptor may be a mechanism underlying enhanced post-synaptic receptor responsiveness in LTP.

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Citations

Sep 29, 2001·Brain Research Bulletin·M P VawterK G Becker
Apr 25, 2000·Brain Research. Brain Research Protocols·H HiraiK Yamada
Jun 30, 2001·Japanese Journal of Pharmacology·N KönigJ M Exbrayat
Sep 10, 2011·Neuropharmacology·Alanna C EastonCathy Fernandes
Oct 1, 1998·Neurobiology of Learning and Memory·G Lynch

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