PMID: 9541236Apr 16, 1998Paper

Calcium- and hydroxyapatite-binding properties of glucuronic acid-rich and iduronic acid-rich glycosaminoglycans and proteoglycans

European Journal of Oral Sciences
G EmberyP Shellis

Abstract

This study describes the interaction of a small chondroitin sulphate proteoglycan and the glycosaminoglycans chondroitin 4-sulphate, dermatan sulphate and heparan sulphate with hydroxyapatite. All macromolecules possessed a high affinity, with the iduronic acid-rich dermatan sulphate and heparan sulphate displaying higher adsorption maxima than the glucuronic acid-rich chondroitin 4-sulphate. At similar concentrations, dermatan sulphate produced a 30% inhibition of hydroxyapatite-induced crystal growth, whilst chondroitin 4-sulphate yielded 50% inhibition. Estimation of the calcium binding capacity of these glycosaminoglycans using equilibrium dialysis indicated that chondroitin 4-sulphate bound five times more calcium than dermatan sulphate at a calcium concentration similar to that of serum. The data indicate a possible important role for chondroitin 4-sulphate in dentinogenesis where it is the dominant glycosaminoglycan, since it could act as a capture point for calcium ions during mineralisation, with the leucine-rich domain of its parent proteoglycan acting as anchor points to type I collagen.

Citations

Feb 24, 2001·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·K HoshiH Ozawa
Sep 7, 2007·Journal of Biomedical Materials Research. Part a·Wolfgang SchneidersStefan Rammelt
Dec 4, 2009·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Hermann EhrlichHartmut Worch
Apr 25, 2003·Archives of Oral Biology·A M MilanG Embery
Sep 26, 2006·Micron : the International Research and Review Journal for Microscopy·Paula DechichiAntônio Wilson de Ameida
Nov 16, 2001·Journal of Orthodontics·R J Waddington, G Embery
Oct 6, 2005·Matrix Biology : Journal of the International Society for Matrix Biology·Julian Robert James AdamsSharon Byers
Apr 20, 2005·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·A K S ArambawattaM Wakita
Dec 3, 2005·Journal of Neuroscience Research·David RamonetNicole Mahy
Aug 8, 2015·Physical Chemistry Chemical Physics : PCCP·Sergio E Ruiz HernandezNora H de Leeuw
Apr 11, 2015·Journal of Proteomics·Zhi LiaoXiao-Min Li
Oct 18, 2001·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·G EmberyM Goldberg
Feb 8, 2006·European Journal of Oral Sciences·Rachael V SugarsMikael Wendel
Oct 2, 2008·Tissue Engineering. Part B, Reviews·Johan BeneschRui L Reis
Nov 13, 2004·The Journal of Biological Chemistry·Yasuo YamakoshiJames P Simmer
Jun 17, 2006·European Journal of Oral Sciences·Anna M MilanRachel J Waddington
Apr 2, 2002·Biochemical and Biophysical Research Communications·Sarah G ReesGraham Embery
Jun 5, 2003·Matrix Biology : Journal of the International Society for Matrix Biology·R J WaddingtonD M Lloyd
Nov 6, 2008·International Journal of Biological Macromolecules·Hermann EhrlichHartmut Worch

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