Calcium- and voltage-gated BK channels in vascular smooth muscle

Pflügers Archiv : European journal of physiology
Alex M DopicoJonathan H Jaggar

Abstract

Ion channels in vascular smooth muscle regulate myogenic tone and vessel contractility. In particular, activation of calcium- and voltage-gated potassium channels of large conductance (BK channels) results in outward current that shifts the membrane potential toward more negative values, triggering a negative feed-back loop on depolarization-induced calcium influx and SM contraction. In this short review, we first present the molecular basis of vascular smooth muscle BK channels and the role of subunit composition and trafficking in the regulation of myogenic tone and vascular contractility. BK channel modulation by endogenous signaling molecules, and paracrine and endocrine mediators follows. Lastly, we describe the functional changes in smooth muscle BK channels that contribute to, or are triggered by, common physiological conditions and pathologies, including obesity, diabetes, and systemic hypertension.

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Citations

Mar 10, 2019·Fundamental & Clinical Pharmacology·Muhammed Fatih DoganKemal Gokhan Ulusoy
Jul 31, 2019·Biological Chemistry·Marina SchreckerInga Hänelt
Feb 13, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Matej VicenPetr Nachtigal
Aug 23, 2020·Antioxidants·Kalina Szteyn, Harpreet Singh
Feb 16, 2020·CNS Drugs·Mohammad Al-Mahdi Al-KaragholiMessoud Ashina
Sep 26, 2019·American Journal of Physiology. Lung Cellular and Molecular Physiology·Aleksandra BabichevaJason X-J Yuan
Jan 8, 2020·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Sung Eun KimSung Joon Kim
Aug 28, 2020·Cephalalgia : an International Journal of Headache·Mohammad Al-Mahdi Al-KaragholiMessoud Ashina
Apr 15, 2019·Pflügers Archiv : European journal of physiology·Retsu Mitsui, Hikaru Hashitani
Aug 31, 2020·The Journal of Pharmacology and Experimental Therapeutics·Kelsey NorthAlex Dopico
Nov 11, 2020·Journal of Biochemistry·Yoshiyuki Rikitake
Jan 1, 2021·Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids·Anna N Bukiya, Alex M Dopico
Nov 21, 2020·American Journal of Respiratory Cell and Molecular Biology·Tatiana ZyrianovaAndreas Schwingshackl
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Methods Mentioned

BETA
FRET
co-immunoprecipitation

Software Mentioned

STREX

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