Calcium: A New Guardian of Naive Pluripotency

Cell Stem Cell
Yuqing Zhu, Jin Zhang

Abstract

In this issue of Cell Stem Cell, MacDougall et al. (2019) utilized a CRISPR mutagenesis screen to identify factors for mESC self-renewal and found that intracellular calcium and nuclear export act in naive pluripotency exit. Combined knockout of Tcf7l1 and the calcium transporter Atp2b1 enabled mESCs to self-renew in the absence of LIF and 2i.

Citations


❮ Previous
Next ❯

Related Concepts

Related Feeds

CRISPR (general)

Clustered regularly interspaced short palindromic repeats (CRISPR) are DNA sequences in the genome that are recognized and cleaved by CRISPR-associated proteins (Cas). CRISPR-Cas system enables the editing of genes to create or correct mutations. Discover the latest research on CRISPR here.

CRISPR for Genome Editing

Genome editing technologies enable the editing of genes to create or correct mutations. Clustered regularly interspaced short palindromic repeats (CRISPR) are DNA sequences in the genome that are recognized and cleaved by CRISPR-associated proteins (Cas). Here is the latest research on the use of CRISPR-Cas system in gene editing.