Calcium acquisition rates do not support age-appropriate gains in total body bone mineral content in prepuberty and late puberty in girls with cystic fibrosis

Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
K J SchulzeKimberly O'Brien

Abstract

Few longitudinal data are available characterizing bone development in adolescents with cystic fibrosis (CF) although this is a critical time for bone mineralization. Dual energy X-ray absorptiometry (DXA) scans were obtained at 1- to 4-year intervals in 18 prepubertal and pubertal girls (age 7-18 years) with CF to determine calcium (Ca) accretion rates and changes (Delta) in total body bone mineral content (TBBMC) and lumbar spine bone mineral density (LS BMD) Z-scores. Daily Ca acquisition rates were calculated assuming TBBMC was composed of 32.2% Ca. Bone Ca accretion averaged 82 mg/day (2.05 mmol/day) [(range:-38 to +197 mg/day (-0.95 to 4.9 mmol/day)] on approximately 1,200 mg/day (30 mmol/day) Ca intakes. Estimated mean peak Ca accretion was 160 mg/day (4 mmol/day) at age 13 years; losses of bone Ca occurred in late puberty. Gains in insulin-like growth factor 1 (IGF-1) predicted Ca accretion (p<0.06). Body mass index (BMI) Z-score predicted LS BMD and TBBMC Z-score cross-sectionally but did not predict DeltaTBBMC Z-score. Changes in TBBMC Z-score paralleled Ca accretion rates with age. Bone Ca accretion in girls with CF fell below rates in healthy girls during prepuberty and late puberty despite Ca intakes approaching re...Continue Reading

References

Jan 1, 1994·The American Journal of Medicine·L K BachrachR B Moss
Jan 1, 1996·The Journal of Pediatrics·R C Henderson, C D Madsen
Jun 1, 1996·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·K J EllisS Abrams
Jun 1, 1996·The Journal of Clinical Endocrinology and Metabolism·S A AbramsJ E Stuff
Sep 1, 1997·The American Journal of Clinical Nutrition·A D MartinS Whiting
Jul 22, 1998·The Journal of Pediatrics·G S BhudhikanokL K Bachrach
Oct 23, 1998·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·K J Ellis, R J Shypailo
Mar 24, 1999·Pediatric Pulmonology·R C Henderson, C D Madsen
Oct 20, 1999·Thorax·C S HaworthJ E Adams
May 10, 2000·The Journal of Pediatrics·L A MortensenB C Marshall
Jun 8, 2000·The Journal of Clinical Endocrinology and Metabolism·S A AbramsK J Ellis
Jun 24, 2000·Annals of the New York Academy of Sciences·K J EllisS A Abrams
Sep 16, 2000·American Journal of Respiratory and Critical Care Medicine·A A IonescuD J Shale
Nov 9, 2000·American Journal of Respiratory and Critical Care Medicine·R M ArisG E Lester
Nov 25, 2000·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·D A BaileyR Mirwald
Mar 21, 2001·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·R P HeaneyC Weaver
Mar 22, 2001·Archives of Disease in Childhood·D S HardinK J Ellis
Sep 26, 2001·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·M S TreuthK J Ellis
Jun 21, 2003·The American Journal of Clinical Nutrition·Kerry J SchulzeBeryl J Rosenstein
Jul 30, 2003·The American Journal of Clinical Nutrition·Robert P Heaney
Apr 16, 2004·Journal of Pediatric Gastroenterology and Nutrition·Rita UjhelyiMiklós Szathmári
Jul 9, 2004·The Journal of Clinical Endocrinology and Metabolism·Kerry J SchulzeBeryl J Rosenstein
Dec 23, 2004·The Journal of Clinical Endocrinology and Metabolism·Robert M ArisTerry B White

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Citations

Jan 1, 2008·Reviews in Endocrine & Metabolic Disorders·Anuradha Viswanathan, Francisco A Sylvester
Oct 21, 2006·Current Opinion in Pulmonary Medicine·Michael P Boyle
Mar 8, 2008·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·I Sermet-GaudelusUNKNOWN Fédération française des centres de ressource et de compétence en mucoviscidose
Nov 26, 2009·Pediatric Clinics of North America·Suzanne H MichelMaria Mascarenhas
Jun 25, 2008·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Steven P ConwayJohn G Truscott
Jun 6, 2018·The Journal of Physiology·Kimberly O O'Brien, Steven A Abrams
Oct 1, 2019·Current Opinion in Pulmonary Medicine·Frédérique Chedevergne, Isabelle Sermet-Gaudelus

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