Calcium-Activated Potassium Channels at Nodes of Ranvier Secure Axonal Spike Propagation

Cell Reports
Jan Gründemann, Beverley A Clark

Abstract

Functional connectivity between brain regions relies on long-range signaling by myelinated axons. This is secured by saltatory action potential propagation that depends fundamentally on sodium channel availability at nodes of Ranvier. Although various potassium channel types have been anatomically localized to myelinated axons in the brain, direct evidence for their functional recruitment in maintaining node excitability is scarce. Cerebellar Purkinje cells provide continuous input to their targets in the cerebellar nuclei, reliably transmitting axonal spikes over a wide range of rates, requiring a constantly available pool of nodal sodium channels. We show that the recruitment of calcium-activated potassium channels (IK, K(Ca)3.1) by local, activity-dependent calcium (Ca(2+)) influx at nodes of Ranvier via a T-type voltage-gated Ca(2+) current provides a powerful mechanism that likely opposes depolarizing block at the nodes and is thus pivotal to securing continuous axonal spike propagation in spontaneously firing Purkinje cells.

References

Aug 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·D HillmanR R Llinás
Sep 25, 1980·Nature·J D Kocsis, S G Waxman
Oct 6, 1997·Proceedings of the National Academy of Sciences of the United States of America·W J JoinerL K Kaczmarek
May 2, 1998·The Journal of General Physiology·B HirschbergN V Marrion
Mar 11, 2000·British Journal of Pharmacology·J K HadleyD A Brown
Jul 8, 2000·Proceedings of the National Academy of Sciences of the United States of America·H WulffK G Chandy
Feb 6, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jérôme J DevauxSteven S Scherer
Feb 12, 2004·Science's STKE : Signal Transduction Knowledge Environment·Ryohei YasudaKarel Svoboda
Jan 14, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Zayd M Khaliq, Indira M Raman
Jan 14, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Pablo MonsivaisMichael Häusser
Jan 25, 2005·Nature Neuroscience·Beverley A ClarkMichael Häusser
Mar 10, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Zongming PanEdward C Cooper
Jul 13, 2006·Journal of Neurophysiology·Chuan-Li ZhangShing Yan Chiu
Apr 21, 2007·The Journal of Comparative Neurology·Su Ying ChangBernardo Rudy
Oct 24, 2008·Frontiers in Cellular Neuroscience·Sergio SolinasEgidio D'Angelo
Feb 3, 2009·Neuron·Kevin J Bender, Laurence O Trussell
Jan 22, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yasuhiro OgawaMatthew N Rasband
May 21, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Amanda FoustDavid A McCormick
Sep 3, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yuguo YuDavid McCormick
Sep 8, 2010·Neuroscience Letters·Matthew N Rasband
Sep 15, 2010·The Journal of General Physiology·Mark A BaileyDaniel C Devor
Oct 29, 2010·The Cerebellum·Haroon AnwarErik De Schutter
Nov 26, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Amanda MierzwaJack Rosenbluth
Apr 27, 2011·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Shing Y Chiu
Apr 30, 2011·Physiological Reviews·Dominique DebanneGisèle Alcaraz
May 20, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Nobuhiko OhnoBruce D Trapp
Feb 7, 2012·Proceedings of the National Academy of Sciences of the United States of America·Jordan D T EngbersRay W Turner
Mar 7, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Arne BattefeldMaarten H P Kole
Jun 11, 2014·Acta Neuropathologica·I Lorena Arancibia-Carcamo, David Attwell
May 8, 2015·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Moritoshi HironoHiroaki Misonou

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Citations

Jan 5, 2016·Acta Pharmacologica Sinica·David WeisbrodBernard Attali
Mar 17, 2017·Neuropharmacology·Moritoshi HironoShiro Konishi
Jun 25, 2019·Glia·Daumante SuminaiteMatthew R Livesey
Jan 20, 2016·Pain·Emmanuel BourinetSophie Laffray
Oct 18, 2019·Frontiers in Cellular Neuroscience·Pepe Alcami, Ahmed El Hady
Jun 20, 2020·ELife·Naomi Ak HanemaaijerMaarten Hp Kole
May 3, 2020·Proceedings of the National Academy of Sciences of the United States of America·Laura C GomezIsabel Llano
Jul 12, 2020·Nature Reviews. Neurology·Catherine LubetzkiAnne Desmazières
Dec 31, 2020·Life·Delphine Pinatel, Catherine Faivre-Sarrailh
Feb 21, 2019·Current Opinion in Neurobiology·Scott A AlpizarMichael B Hoppa
Aug 5, 2021·Journal of Neurophysiology·Wenke LiuRobin L Davis
Aug 24, 2021·The Journal of Physiology·Jürgen R Schwarz
Jul 7, 2021·Nature Communications·Daneck Lang-OuelletteAlanna J Watt

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