Calcium-activated sustained firing responses distinguish accessory from main olfactory bulb mitral cells.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
G ShpakS Wagner

Abstract

Many mammals rely on pheromones for mediating social interactions. Recent studies indicate that both the main olfactory system (MOS) and accessory olfactory system (AOS) detect and process pheromonal stimuli, yet the functional difference between these two chemosensory systems remains unclear. We hypothesized that the main functional distinction between the MOS and AOS is the type of sensory information processing performed by each system. Here we compared the electrophysiological responses of mitral cells recorded from the accessory olfactory bulb (AOB) and main olfactory bulb (MOB) in acute mouse brain slices to various stimuli and found them markedly different. The response of MOB mitral cells to brief (0.1 ms, 1-100 V) stimulation of their sensory afferents remained transient regardless of stimulus strength, whereas sufficiently strong stimuli evoked sustained firing in AOB mitral cells lasting up to several minutes. Using EPSC-like current injections (10-100 pA, 10 ms rise time constant, 5 s decay time constant) in the presence of various synaptic blockers (picrotoxin, CGP55845, APV, DNQX, E4CPG, and MSPG), we demonstrated that this difference is attributable to distinct intrinsic properties of the two neuronal populations...Continue Reading

Citations

Jun 5, 2014·ELife·Joseph F BerganCatherine Dulac
Feb 10, 2016·Frontiers in Neuroscience·Victor Vargas-BarrosoJorge A Larriva-Sahd
Aug 3, 2013·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Edda KastenhuberStephan C F Neuhauss
Jan 18, 2014·British Journal of Pharmacology·R GuinamardC A Del Negro
May 23, 2014·Frontiers in Neuroscience·Livio Oboti, Paolo Peretto
Feb 24, 2017·The Journal of Physiology·Zhenbo HuangDebra Ann Fadool
Jun 18, 2017·ELife·Yuan GaoIan G Davison
Feb 15, 2018·Frontiers in Cellular Neuroscience·Denise RiquelmeElias Leiva-Salcedo
Feb 12, 2017·The Journal of Experimental Biology·Warren W GreenBarbara S Zielinski
Sep 27, 2018·Chemical Senses·Julia MohrhardtMarc Spehr
Apr 5, 2020·Scientific Reports·Livio Oboti, Katie Sokolowski
May 18, 2021·Frontiers in Neuroanatomy·Denise RiquelmeElias Leiva-Salcedo
Jun 3, 2021·International Journal of Molecular Sciences·Denise RiquelmeElias Leiva-Salcedo

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