Calcium activity in different classes of myenteric neurons underlying the migrating motor complex in the murine colon.

The Journal of Physiology
Peter O BayguinovTerence K Smith

Abstract

The spontaneous colonic migrating motor complex (CMMC) is a cyclical contractile and electrical event that is the primary motor pattern underlying fecal pellet propulsion along the murine colon. We have combined Ca(2+) imaging with immunohistochemistry to determine the role of different classes of myenteric neurons during the CMMC. Between CMMCs, myenteric neurons usually displayed ongoing but uncoordinated activity. Stroking the mucosa at the oral or anal end of the colon resulted in a CMMC (latency: 6 to 10 s; duration: 28 s) that consisted of prolonged increases in activity in many myenteric neurons that was correlated to Ca(2+) transients in and displacement of the muscle. These neurons were likely excitatory motor neurons. Activity in individual neurons during the CMMC was similar regardless of whether the CMMC occurred spontaneously or was evoked by anal or oral mucosal stimulation. This suggests that convergent interneuronal pathways exist which generate CMMCs. Interestingly, Ca(2+) transients in a subset of NOS +ve neurons were substantially reduced during the CMMC. These neurons are likely to be inhibitory motor neurons that reduce their activity during a complex (disinhibition) to allow full excitation of the muscle. ...Continue Reading

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Citations

Sep 11, 2012·American Journal of Physiology. Gastrointestinal and Liver Physiology·Dante J HerediaTerence K Smith
Apr 24, 2010·American Journal of Physiology. Gastrointestinal and Liver Physiology·Eamonn J DicksonTerence K Smith
Aug 1, 2015·The Journal of Physiology·Terence K Smith, Michael D Gershon
Aug 1, 2015·The Journal of Physiology·Terence K Smith, Michael D Gershon
Oct 13, 2012·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·A E Bharucha
May 29, 2012·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·T OkamotoT K Smith
Feb 16, 2012·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·P O BayguinovT K Smith
Jul 2, 2015·Journal of Neurogastroenterology and Motility·Werend BoesmansPieter Vanden Berghe
Apr 4, 2015·Journal of Pharmacological Sciences·Yohei TokitaMasahiro Yamamoto
Aug 11, 2018·American Journal of Physiology. Gastrointestinal and Liver Physiology·Alexander D VincentJan D Huizinga
Jun 16, 2010·The Journal of Physiology·Dante J HerediaTerence K Smith
Jan 28, 2014·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·T OkamotoT K Smith
Jul 4, 2019·American Journal of Physiology. Gastrointestinal and Liver Physiology·Thomas W GouldTerence K Smith
Oct 30, 2016·American Journal of Physiology. Gastrointestinal and Liver Physiology·Terence Keith Smith, Sang Don Koh
Sep 17, 2019·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Rachel M Gwynne, Joel C Bornstein
Oct 22, 2020·American Journal of Physiology. Gastrointestinal and Liver Physiology·N J SpencerJ D Wood
Apr 25, 2021·Progress in Neurobiology·Matthew J Broadhead, Gareth B Miles

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