Calcium and fertilization: the beginning of life

Trends in Biochemical Sciences
Luigia SantellaFrancesco Moccia

Abstract

The explosive increase in Ca2+ that occurs in the cytosol at fertilization is brought about by the activation of Ca2+-release channels in the intracellular stores. Inositol 1,4,5-trisphosphate (InsP3) is traditionally considered to be the messenger that initiates the increase and spreading of the activating Ca2+ wave. In line with this hypothesis, recent evidence suggests that the penetrating sperm delivers into mammalian eggs a novel isoform of phospholipase C (PLC), which promotes the formation of InsP3. By contrast, data from echinoderms studies indicate that the newly discovered second messenger nicotinic adenine dinucleotide phosphate (NAADP) promotes an initial, localized increase in Ca2+, which is then followed by the InsP3-mediated globalization of the Ca2+ wave. The mechanism by which the interacting sperm triggers the production of NAADP and subsequently that of InsP3 remains obscure.

References

Jun 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·V D Vacquier, G W Moy
Feb 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·E B RidgwayL F Jaffe
Aug 1, 1990·Developmental Biology·K ChibaL A Jaffe
Nov 1, 1988·Cell Differentiation and Development : the Official Journal of the International Society of Developmental Biologists·L A JaffeF Shilling
May 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·R A Steinhardt, D Epel
Jan 1, 1995·Trends in Biochemical Sciences·K Ohlendieck, W J Lennarz
Dec 15, 1995·The Biochemical Journal·C M Perez-TerzicD E Clapham
Nov 14, 1998·The American Journal of Physiology·M WildingB Dale
Dec 16, 1998·Developmental Biology·N Hirohashi, W J Lennarz
Sep 24, 1999·Developmental Biology·T Kishimoto
Jun 13, 2000·The Journal of Cell Biology·B J MillerD G Myles
Aug 19, 2000·Current Topics in Developmental Biology·D Kline
Oct 24, 2000·Biology of the Cell·A McDougallM Whitaker
Oct 24, 2000·Biology of the Cell·B Ciapa, S Chiri
Oct 24, 2000·Biology of the Cell·C Finaz, S Hammami-Hamza
Jun 8, 2001·Annual Review of Biochemistry·S G Rhee
Jul 5, 2001·Frontiers in Bioscience : a Journal and Virtual Library·A L Abbott, T Ducibella
Oct 20, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·D LimL Santella
Jan 11, 2002·Developmental Biology·Christian SardetJanet Chênevert
Jan 19, 2002·Biochemical and Biophysical Research Communications·Gilda A NuscoLuigia Santella
Apr 27, 2002·Nature·Julie D R Reimann, Peter K Jackson
Apr 30, 2002·Developmental Biology·Linda L RunftLisa M Mehlmann
Jun 28, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Dmitri LimLuigia Santella

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Citations

Jan 18, 2007·Proceedings of the National Academy of Sciences of the United States of America·Huayu QiDavid E Clapham
Jun 25, 2014·Biochemical and Biophysical Research Communications·Jong T ChunLuigia Santella
Dec 24, 2005·Physiological Reviews·Michael Whitaker
Jan 15, 2008·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Michael Whitaker, Jim Smith
Feb 12, 2008·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Michael Whitaker
Jun 23, 2012·PloS One·Filip VasilevLuigia Santella
Feb 9, 2013·The Journal of Biological Chemistry·Chun-Chang ChenChe-Kun James Shen
Sep 2, 2005·Nature Reviews. Genetics·Stephen A Krawetz
Jul 19, 2005·Biochemical and Biophysical Research Communications·Fabiana Geraci, Giovanni Giudice
Jun 11, 2011·Toxicological Sciences : an Official Journal of the Society of Toxicology·Annalisa PinsinoValeria Matranga
Mar 13, 2013·The Journal of Cell Biology·Anthony J MorganAntony Galione
Dec 12, 2012·Cell Calcium·Isabela Ramos, Gary M Wessel
Jul 26, 2011·Science China. Life Sciences·Luigia Santella, Jong T Chun
May 23, 2009·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Sabine SchäferAngela Koehler
Sep 28, 2007·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·F Moccia
Sep 25, 2015·Micron : the International Research and Review Journal for Microscopy·Amin GolpourHamid Niksirat
Nov 6, 2008·Acta Physiologica·J T Chun, L Santella
Aug 1, 2013·Molecular Reproduction and Development·Junaid KashirStephen A Stricker
Nov 16, 2011·Genesis : the Journal of Genetics and Development·Wendy L Johnston, James W Dennis
Aug 8, 2006·Biochemical and Biophysical Research Communications·F MocciaLuigia Santella
Aug 1, 2006·Biochemical and Biophysical Research Communications·Gilda A NuscoLuigia Santella
Aug 19, 2015·Reproductive Biomedicine Online·Luigia Santella, Brian Dale
May 23, 2015·Biochemical and Biophysical Research Communications·Luigia SantellaJong T Chun
Dec 13, 2005·Current Biology : CB·Michael L StitzelGeraldine Seydoux
Aug 29, 2012·Biochemical and Biophysical Research Communications·Luigia SantellaJong T Chun
May 29, 2007·Developmental Biology·Diane C Slusarski, Francisco Pelegri
Aug 27, 2014·Animal Reproduction Science·Hamid NiksiratPavel Kozák
Mar 21, 2006·Developmental Biology·Francesco MocciaLuigia Santella
Oct 24, 2006·Developmental Biology·Michelle M RouxKathy R Foltz
Oct 10, 2013·Biochemical and Biophysical Research Communications·Jong T ChunLuigia Santella
Jul 5, 2008·Developmental Biology·Keiichiro KyozukaLuigia Santella
Mar 28, 2006·Current Topics in Developmental Biology·Julian L Wong, Gary M Wessel
Aug 27, 2016·Scientific Reports·Nadia RuoccoLuigia Santella
Nov 3, 2016·Zygote : the Biology of Gametes and Early Embryos·Isao Takahashi, Keiichiro Kyozuka
Aug 1, 2018·International Journal of Environmental Research and Public Health·Dinh Nam TranEui-Bae Jeung
Aug 10, 2019·Zygote : the Biology of Gametes and Early Embryos·Nunzia LimatolaLuigia Santella
Apr 29, 2020·Zygote : the Biology of Gametes and Early Embryos·M JamilR Cadi
May 16, 2007·Médecine sciences : M/S·Jean-Philippe WolfBrigitte Ciapa
Jan 13, 2017·Human Reproduction·Katrien De ClercqJoris Vriens

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