Calcium and phosphorous deficiencies alter the lipid composition and fluidity of intestinal basolateral membranes

Comparative Biochemistry and Physiology. Part A, Physiology
Nori G Tolosa de Talamoni

Abstract

Steady-state fluorescence polarization and lipid composition studies were undertaken on intestinal basolateral membranes (BLM) from chicks adapted to a calcium deficient (low Ca) or a phosphorous deficient diet (low P). The fluorescence anisotropy showed that fluidity of intestinal BLM was increased by the mineral deprivations, but the response of the membranes varied with the specific fluorophore used. The "static" component of fluidity, assessed by 1,6-diphenyl-1,3,5-hexatriene (DPH), was increased whereas the "dynamic" component, monitored with DL-12-(9-anthroyloxy)-stearic acid (12-AS), was not modified. Low P diet produced significant changes in lipid composition such as a decrease in the cholesterol content and in the sphyngomyelin (Sph) and phosphatidylserine plus phosphatidylinositol fractions (PS + PI) and increment in the phosphatidylcholine (PC) proportion. The percent of monounsaturated fatty acids was increased by the low P diet due mainly to an increase in the oleic acid fraction. Minor changes such as a decrease in the palmitic acid and increases in the 22:5n3 and 22:6n3 fatty acids were caused by Ca deficiency. The alteration of the biochemical and biophysical membrane properties of the BLM of the mineral defici...Continue Reading

References

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Citations

Oct 20, 2009·Nutrition Research Reviews·Viviana CentenoNori Tolosa de Talamoni
Feb 13, 2010·The Journal of Nutritional Biochemistry·Adriana PérezNori G Tolosa de Talamoni
Oct 16, 2015·Nutrition Research Reviews·Vanessa ArecoNori Tolosa de Talamoni
Nov 6, 2004·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Viviana A CentenoNori G Tolosa de Talamoni
May 20, 2017·World Journal of Gastroenterology : WJG·Gabriela Diaz de BarbozaNori Tolosa de Talamoni

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