PMID: 6413711Jul 1, 1983Paper

Calcium and phosphorus in neonatal parenteral nutrition solutions

JPEN. Journal of Parenteral and Enteral Nutrition
R L PooleJ A Kerner

Abstract

Due to calcium and phosphorus solubility problems in parenteral nutrition solutions, it is difficult to provide the premature infant with enough of these two minerals for adequate bone mineralization. In order to determine the maximum amounts of both Ca and P soluble in neonatal parenteral nutrition solutions, we employed the following procedure: (1) using concentrations of dextrose 10 to 25% and amino acid 0.5 to 4.0% with standard electrolyte and vitamin concentrations, Ca and P additions were sequentially made to determine the critical concentrations at which precipitates formed; (2) the pH of each test solution was determined; (3) all test solutions were incubated for 30 hr at room temperature; (4) following incubation, all tests were visually observed for calcium-phosphate crystals; (5) the solutions not obviously precipitated were filtered using black Millipore filters to determine the presence of any microprecipitates. Multiple graphs of Ca and P solubility in various dextrose/amino acid solutions were prepared from data generated by the study. The Ca and P interaction is primarily pH sensitive. Factors affecting the solution pH include both dextrose and amino acid concentrations. Our study showed that increases in amino...Continue Reading

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Citations

Aug 21, 2014·Journal of Analytical Methods in Chemistry·John-Bruce D GreenThomas Gonyon
Apr 30, 2005·Journal of Perinatology : Official Journal of the California Perinatal Association·David H Adamkin
Jan 1, 1989·Intensive Care Medicine·M PiertR Hettich
Jan 1, 1986·Journal of the American College of Nutrition·S NiermeyerB J Quissell
Apr 1, 1990·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·I Z Kovar, J B Morgan
Oct 1, 1987·Journal of Clinical Pharmacy and Therapeutics·M C Allwood
Sep 1, 1984·Journal of Clinical and Hospital Pharmacy·M C Allwood
Oct 1, 1991·Journal of Pediatric Oncology Nursing : Official Journal of the Association of Pediatric Oncology Nurses·J Robertson
May 1, 1986·JPEN. Journal of Parenteral and Enteral Nutrition·L A LesterZ Corpuz
Mar 4, 2015·JPEN. Journal of Parenteral and Enteral Nutrition·Roula MerhebSuchitra Nelson
Jul 31, 2013·JPEN. Journal of Parenteral and Enteral Nutrition·Thomas GonyonJohn-Bruce D Green
Mar 1, 1985·JPEN. Journal of Parenteral and Enteral Nutrition·D Watson
Jan 1, 1996·JPEN. Journal of Parenteral and Enteral Nutrition·M W MacKayD Jackson
Jan 1, 1996·JPEN. Journal of Parenteral and Enteral Nutrition·S E HillJ C Perkinson
Mar 1, 1989·JPEN. Journal of Parenteral and Enteral Nutrition·J B KnowlesM D Sitrin
May 1, 1990·JPEN. Journal of Parenteral and Enteral Nutrition·C J RollinsJ N Udall
Nov 1, 1991·JPEN. Journal of Parenteral and Enteral Nutrition·B DunhamK Nichols
May 18, 2007·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Marcus Ferrone, Matthew Geraci
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Mar 7, 2019·The Journal of Pediatric Pharmacology and Therapeutics : JPPT : the Official Journal of PPAG·Heather J OwenSteve T Wyrwa
Aug 23, 2000·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·A L Buchman, A Moukarzel
Mar 1, 1991·Annals of Clinical Biochemistry·P D Mayne, I Z Kovar

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