PMID: 3746681Apr 1, 1986Paper

Calcium and strontium activation of single skinned muscle fibres of normal and dystrophic mice

The Journal of Physiology
R H FinkD A Williams

Abstract

Differences in contractile activation by Ca2+ and Sr2+ between various types of normal and dystrophic murine muscle fibres were investigated using mechanically skinned fibres derived from soleus and extensor digitorum longus (e.d.l.) muscles of normal and dystrophic mice of strain 129ReJ. In terms of contractile activation, the normal e.d.l. muscle was found to consist of one relatively homogeneous population of muscle fibres characterized by steep force-pCa and force-pSr curves, low sensitivity to Ca2+ and very low sensitivity to Sr2+. Normal soleus muscles contained two fibre populations of similar size which could be distinguished on the basis of their contractile activation properties. The first fibre population was characterized mainly by its shallow force-pCa and force-pSr curves, high Ca2+ sensitivity, high Sr2+ sensitivity and the occurrence of large, slow force oscillations of myofibrillar origin. The second fibre population was characterized by force-pCa and force-pSr curves of steepness intermediate between those of normal e.d.l. and those of the first fibre population of normal soleus, by faster myofibrillar force oscillations and by low sensitivity to Ca2+ and Sr2+. The dystrophic e.d.l. fibre population had contra...Continue Reading

Citations

Mar 1, 1991·Pflügers Archiv : European journal of physiology·G S LynchD A Williams
May 1, 1995·Pflügers Archiv : European journal of physiology·C CordonnierY Mounier
Jan 1, 1996·European Journal of Applied Physiology and Occupational Physiology·U DillmannK Schimrigk
Nov 1, 1994·Acta Physiologica Scandinavica·G S LynchD A Williams
Sep 30, 2010·The Journal of Physiology·Frank Vincenzo de PaoliOle Baekgaard Nielsen
Mar 30, 2010·Acta Physiologica·M CanepariR Bottinelli
Apr 19, 2005·Neuromuscular Disorders : NMD·Julie D AtkinSurindar S Cheema
Jun 1, 1995·Clinical and Experimental Pharmacology & Physiology·G S LynchD A Williams
Jul 28, 2001·Clinical and Experimental Pharmacology & Physiology·G M Stephenson
Oct 16, 1999·Acta Physiologica Scandinavica·F Gustafsson, N Holstein-Rathlou
Aug 1, 1987·Pflügers Archiv : European journal of physiology·R H Fink, D G Stephenson
Aug 1, 1988·Muscle & Nerve·T Gordon, R B Stein
Jun 23, 2006·Clinical and Experimental Pharmacology & Physiology·Huong H Trinh, Graham D Lamb
Aug 15, 2009·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Marie-Louise BangMarco Linari
Feb 27, 2004·American Journal of Physiology. Cell Physiology·Brett O'ConnellGabriela M M Stephenson
Apr 14, 2006·American Journal of Physiology. Cell Physiology·M F PattersonD G Stephenson
Oct 13, 2000·American Journal of Physiology. Cell Physiology·S K BortolottoG M Stephenson
Apr 12, 2001·Journal of Applied Physiology·P KischelY Mounier
Feb 1, 1990·Journal of Muscle Research and Cell Motility·G J Wilson, D G Stephenson
Jul 28, 2019·Journal of Muscle Research and Cell Motility·C J Barclay, B S Launikonis

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