PMID: 8466723Mar 1, 1993Paper

Calcium antagonists and atherosclerosis. The Multicenter Isradipine/Diuretic Atherosclerosis Study

American Journal of Hypertension
C D FurbergJ R Sowers

Abstract

The Multicenter Isradipine/Diuretic Atherosclerosis Study (MIDAS) is a double-blind, randomized, controlled clinical trial comparing the effects of isradipine and hydrochlorothiazide on the progression or regression of early carotid atherosclerosis in 883 hypertensive patients. Assessment of the outcome is by B-mode ultrasonographic measurement of early lesions (as reflected by intimal-medial wall thickening) at baseline and semiannually over 36 months. At baseline, the participants' mean age was 58.5 years. The study population was 78.6% male and 72.4% white. The average resting systolic and diastolic blood pressures were 149.8 and 96.5 mm Hg, respectively. Mean total serum cholesterol and low-density lipoprotein (LDL)-cholesterol levels were 216.2 mg/dL and 146.6 mg/dL, respectively. Risk factors for coronary artery disease were balanced at baseline between the two study groups. The mean maximum intimal-medial thickness at baseline (measured in the near and far walls of three segments for both carotid arteries) was 1.17 +/- 0.20 mm; the mean intimal-medial thickness of the single thickest lesion was 2.11 +/- 0.51 mm. Cross-sectional analyses show that intimal-medial thickness correlates independently with male gender, age, nu...Continue Reading

Citations

Nov 1, 1994·Journal of Internal Medicine·C D FurbergT E Craven

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