Calcium antagonists and the ischaemic myocardium

European Heart Journal
W G Nayler, W J Sturrock

Abstract

We have investigated whether Ca2+ antagonists reduce the amount of noradrenaline (NA) lost from the myocardium during periods of ischaemia and reperfusion. Hearts obtained from adult, male, normotensive Sprague-Dawley rats were perfused at 37 degrees C before being made globally ischaemic for 15 or 60 min and assayed for catecholamines. Some of these hearts were reperfused. Aerobic perfusion for 90 min failed to cause a significant loss of left ventricular NA. Ischaemia for 15 min followed by reperfusion for 15 min, and ischaemia for 60 min with or without reperfusion caused a significant loss of NA. The loss of NA caused by 15 min ischaemia and reperfusion was abolished or attenuated by verapamil, nifedipine, nitrendipine, nisoldipine and diltiazem.

Citations

Aug 1, 1994·Cardiovascular Drugs and Therapy·R FerrariO Visioli
Dec 1, 1988·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·J L Lear

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