Calcium-Based, Antibiotic-Loaded Bone Substitute as an Implant Coating: A Pilot Clinical Study

Journal of Bone and Joint Infection
Nicola LogolusoCarlo Luca Romanò

Abstract

Background: Implant-related infections remain a major complication after orthopaedic surgery. Antibacterial coating of implants may prevent bacterial adhesion and biofilm formation. However, in spite of extensive preclinical research in the field, antibacterial coatings to protect orthopaedic implants in the clinical setting remain particularly few. The aim of the present study is to evaluate the safety of a calcium-based, antibiotic-loaded bone substitute as an antibacterial coating of cementless joint prosthesis. Methods: From March 2013 to August 2015, 20 consecutive patients scheduled for cementless or hybrid two-stage revision surgery for peri-prosthetic joint infection were included in this prospective, observational, pilot study. Cerament G or Cerament V, a gentamicin or vancomycin-loaded calcium-based resorbable bone substitute (60% calcium sulphate, 40% hydroxyapatite), was applied at surgery on the stem surface of hip (n=7) or knee (n=13) revision prosthesis. After surgery, all patients underwent clinical (HHS or KSS and SF-12 score), laboratory and radiographic evaluation at 3, 6 and 12 months and yearly thereafter. Results: At a minimum of 12 months follow-up, 19/20 (95%) patients showed no recurrence of infection a...Continue Reading

References

Jul 6, 2000·Drugs·K Kanellakopoulou, E J Giamarellos-Bourboulis
Jan 31, 2002·Acta Orthopaedica Scandinavica·H van de BeltH J Busscher
Apr 26, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Joseph R Lentino
Nov 16, 2004·The Orthopedic Clinics of North America·John JansenJoop Wolke
Nov 24, 2004·Clinical Orthopaedics and Related Research·Charalampos G ZalavrasPaul Holtom
Aug 2, 2005·Clinical Orthopaedics and Related Research·Arlen D Hanssen
Oct 21, 2009·Journal of Materials Science. Materials in Medicine·T Fintan MoriartyR Geoff Richards
Nov 12, 2009·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Antonio AbramoMagnus Tägil
Nov 30, 2010·Acta Orthopaedica·Esa JämsenLars Lidgren
Aug 13, 2011·European Orthopaedics and Traumatology·Carlo Luca RomanòLorenzo Drago
Aug 18, 2012·International Journal of Biomaterials·Konstantinos Anagnostakos, Katrin Schröder
Aug 1, 2013·Journal of Orthopaedic Surgery and Research·Vasilis ZampelisJian-Sheng Wang
Oct 25, 2013·Clinical Orthopaedics and Related Research·William Cats-BarilJavad Parvizi
May 29, 2014·Journal of Materials Science. Materials in Medicine·V CampanaG Logroscino
Jul 15, 2015·Bone·Elena García-GaretaGordon W Blunn
Oct 3, 2015·Journal of Orthopaedic Surgery and Research·Carlo Luca RomanòLorenzo Drago

❮ Previous
Next ❯

Citations

Jul 17, 2020·Journal of Bone and Joint Infection·Olga D SavvidouPanayiotis J Papagelopoulos
Dec 16, 2017·Bioengineering·Jeffery A WeismanDavid K Mills
Aug 28, 2020·Therapeutics and Clinical Risk Management·Holger FreischmidtThorsten Guehring
Feb 18, 2021·The International Journal of Artificial Organs·Antonio Pellegrini, Claudio Legnani

❮ Previous
Next ❯

Software Mentioned

BoneSupport

Related Concepts

Related Feeds

Aminoglycosides

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Aminoglycosides (ASM)

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Biofilms

Biofilms are adherent bacterial communities embedded in a polymer matrix and can cause persistent human infections that are highly resistant to antibiotics. Discover the latest research on Biofilms here.