PMID: 1195334Apr 23, 1975Paper

Calcium-binding of Synaptosomes isolated from rat brain cortex. II. Inhibitory effects of magnesium ions and some other cations

The Journal of Membrane Biology
K KaminoA Inouye

Abstract

As in our previous report (Kamino, Uyesaka & Inouye, J. Membrane Biol. 17:13 1974), the absorbance changes of murexide caused by Ca2+ and followed up by a dual wavelength spectrophotometer were applied to measure synaptosomal Ca2+-binding in the presence of cations such as Rb+, Mn2+ or La3+. All the cations tested showed a significant inhibition of synaptosomal Ca2+-binding except Li+. The inhibitory effects could be divided into the following three categories: (1) noncompetive, co-operative K+-type, which includes alkali metal ions. The potency of inhibition is K+ greater than Rb+ greater than Cs+ greater than Li+, Na+ =0; (2) competitive Mn2+ -type which includes many divalent cations. The inhibitory potency was found to be in the following order: Mn2+ greater than Sr2+ greater than Cd2+, Ba2+ greater than Mg2+; (3) nonspecific, noncompetitive La3+ -type; among the cations tested, La3+ and Ce3+ were found to markedly reduce the Ca-binding capacity of synaptosomal particles, resulting in a noncompetitive inhibition, at least in the range of Ca2+ concentration used.

References

Sep 1, 1972·Biochimica Et Biophysica Acta·N Krasnow
Jan 1, 1973·The Journal of Physiology·J D Cooke, D M Quastel
Jan 1, 1973·The Journal of Physiology·J D CookeD M Quastel
Dec 1, 1972·Journal of Neurochemistry·D J WolffF L Siegel
Oct 25, 1973·Biochimica Et Biophysica Acta·V M Madeira, M C Antunes-Madeira
Nov 30, 1973·Biochimica Et Biophysica Acta·K KaminoA Inouye
Apr 21, 1972·Science·U Meiri, R Rahamimoff
Sep 1, 1972·The Journal of Cell Biology·G A Langer, J S Frank
Nov 1, 1967·The Journal of Physiology·F A Dodge, R Rahamimoff
Jan 1, 1967·The Journal of General Physiology·S Hagiwara, K Takahashi
Oct 16, 1950·The Journal of Physiology·D K HILL
Apr 1, 1952·The Journal of Physiology·J DEL CASTILLO, L STARK

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Citations

Jan 1, 1981·Neuroscience and Biobehavioral Reviews·R D Myers, D H Ross
Jun 16, 1978·Brain Research·E K Silbergeld, H S Adler
Mar 1, 1985·Kidney International·A J Adler, G M Berlyne

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