Calcium-catalyzed carboarylation of alkynes

Chemistry : a European Journal
Liang Fu, Meike Niggemann

Abstract

The first transition-metal-free carboarylation of alkynes with commercial and readily available alcohols as alkylating agents was realized in the presence of an environmentally benign calcium catalyst. Thereby, a novel protocol for the one-step synthesis of highly congested, all-carbon tetrasubstituted alkenes, as incorporated in potentially bioactive, complex dihydronaphthalene, chromene and dihydroquinoline structures, is provided. The reaction features an unprecedented, particularly wide substrate scope, good functional-group tolerance and simple experimental operation under mild reaction conditions.

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Citations

Apr 4, 2017·Chemistry : a European Journal·Liang FuMeike Niggemann
Apr 4, 2017·Chemistry : a European Journal·Meike NiggemannHelena Damsen
Apr 25, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Qiu-Chi ZhangTeck-Peng Loh
Apr 7, 2016·Chemical Communications : Chem Comm·T Stopka, M Niggemann
Aug 24, 2017·Angewandte Chemie·Tobias StopkaNuno Maulide
Jul 2, 2019·Chemical Communications : Chem Comm·Ashley J Basson, Mark G McLaughlin
Sep 10, 2019·Angewandte Chemie·Abdusalom A SuleymanovKay Severin
Jul 3, 2015·Chemistry : a European Journal·David LeboeufVincent Gandon
Nov 4, 2020·Angewandte Chemie·Abdusalom A Suleymanov, Kay Severin
Dec 17, 2019·Organic Letters·Peizhong XieTeck-Peng Loh
Jan 31, 2020·Organic Letters·Peizhong XieTeck-Peng Loh
Mar 27, 2020·The Journal of Organic Chemistry·Ashley Basson, Mark Gerard McLaughlin
Aug 4, 2018·The Journal of Organic Chemistry·Wangsheng LiuHao Guo

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