Calcium-channel blockade (nitrendipine) in combination with ACE inhibition (captopril) in the treatment of mild to moderate hypertension

Cardiovascular Drugs and Therapy
C GennariP Buracchi

Abstract

The antihypertensive efficacy of a combination of calcium-channel blockers and angiotensin-converting-enzyme (ACE) inhibitors in severe primary hypertension is well known, but a synergistic action of this drug combination in mild to moderate primary hypertension is still not established. Therefore, the aim of the present study was to evaluate the efficacy and tolerability of monotherapy with nitrendipine (20 mg) or captopril (100 mg), and of their combination (nitrendipine 10 mg plus captopril 50 mg), in patients suffering from mild to moderate primary hypertension, according to a single-blind, randomized, placebo-controlled design. After the first 4-week monotherapy period, both nitrendipine and captopril induced a significant decrease in systolic and diastolic blood pressure (BP) (p less than 0.001). Furthermore, nitrendipine caused a significant increase in heart rate (HR), while no change in HR was observed in patients treated with captopril. Several side effects were observed, both in the nitrendipine-treated patients (facial flushing, headache, malleolar edema) and in the captopril-treated patients (initial hypotension, dizziness, gastrointestinal disorders). However, these side effects were mild and were well tolerated. ...Continue Reading

References

Oct 20, 1979·Lancet·A B Atkinson, J I Robertson
Jan 1, 1977·Annual Review of Pharmacology and Toxicology·A Fleckenstein
Jan 1, 1986·American Journal of Nephrology·R PieriA Pirrelli
Nov 1, 1971·Die Naturwissenschaften·F Bossert, W Vater
Mar 1, 1970·The Journal of Physiology·G W Beeler, H Reuter
Jan 1, 1984·Journal of Cardiovascular Pharmacology·C ThananopavarnM P Sambhi
Feb 1, 1982·European Journal of Clinical Investigation·F R Bühler, L Hulthén
Jul 1, 1980·Hypertension·R C TaraziR J Cody
Jan 28, 1982·The New England Journal of Medicine·D G VidtF M Fouad
Aug 1, 1961·The Journal of Physiology·R H FOXG P LEWIS

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Citations

Aug 1, 1993·Journal of Clinical Pharmacology·W H FrishmanA Cretkovic
May 14, 2009·Vascular Health and Risk Management·Bernard Waeber, Luis M Ruilope
Mar 21, 1998·Clinical and Experimental Hypertension : CHE·H GavrasE Conradi
Jun 27, 2008·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Alessandra GaliotoPaolo Angeli
Apr 12, 2008·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Boris GojanovicBernard Waeber
Oct 7, 2020·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Jessica HuangBetty S Chan

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