Calcium channel blockers differentially modulate cytokine production by peripheral blood mononuclear cells

Circulation Journal : Official Journal of the Japanese Circulation Society
Akira MatsumoriYoshisuke Nose

Abstract

Calcium channel blockers (CCB) are known to modulate immune reactions, so the present study was performed to examine the effects of various CCBs that have shown different effects on transcription factors and on the production of pro-inflammatory cytokines by human peripheral blood mononuclear cells (PBMC). PBMC from healthy volunteers were isolated by Ficoll-paque density centrifugation. To study the effect of CCBs, the PBMC were stimulated with lipopolysaccharide or concanavalin A. After 24 h of incubation, the supernatants were harvested and the interleukin (IL)-1alpha, -1beta, and -6, tumor necrosis factor (TNF)-alpha, and interferon (IFN)-gamma levels were determined by specific enzyme-linked immunosorbent assay. The production of IL-1alpha and -1beta stimulated with lipopolysaccharide was significantly increased in the presence of amlodipine. In contrast, nifedipine and verapamil suppressed the production of IL-1beta, TNF-alpha, and IFN-gamma. Amlodipine and diltiazem significantly increased production of IL-1alpha stimulated with concanavalin A. Nifedipine inhibited production of IL-1alpha, IL-6, and IFN-gamma. Verapamil suppressed production of IFN-gamma. Differential modulation of cytokine production was seen with vario...Continue Reading

Associated Clinical Trials

May 27, 2015·Benjamin Bleier, Benjamin Bleier

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Citations

Nov 3, 2011·Molecular Therapy : the Journal of the American Society of Gene Therapy·Anniina KoskiAkseli Hemminki
Oct 25, 2012·Herz·A Matsumori
Jan 22, 2013·Arthritis and Rheumatism·Kathleen A SlukaGary S Firestein
Jul 25, 2015·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Itsuro KazamaMasahiro Tachi
Oct 22, 2014·International Forum of Allergy & Rhinology·Benjamin S BleierXue Han
Sep 18, 2012·Immunopharmacology and Immunotoxicology·Itsuro KazamaMitsunobu Matsubara
Aug 11, 2015·Frontiers in Immunology·Bennett DavenportAnne-Laure Perraud
Apr 30, 2013·Toxicon : Official Journal of the International Society on Toxinology·K E Cervantes-LuevanoAlexei Licea
Jan 27, 2017·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Daisuke SuetaSeiji Hokimoto
Jul 20, 2018·Fundamental & Clinical Pharmacology·Marie-Laure LarocheHélène Geniaux
Feb 6, 2018·Advanced Pharmaceutical Bulletin·Tahereh Eteraf-OskoueiMoslem Najafi
Apr 7, 2011·Current Opinion in Infectious Diseases·Wenling Liu, Akira Matsumori
Dec 22, 2020·International Immunopharmacology·Ashkan BagheriManica Negahdaripour
Feb 23, 2021·Expert Review of Clinical Pharmacology·Yang LoTsen-Fang Tsai
Jul 24, 2021·Diabetes & Metabolic Syndrome·Mochamad Yusuf AlsagaffMaya Qurota A'yun

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