Calcium channel blockers in the management of hypertension in the elderly

Cardiovascular & Hematological Agents in Medicinal Chemistry
Francisco J Caballero-Gonzalez

Abstract

The aging population is rapidly increasing, and is mainly due to medical advances and the control of chronic diseases, with a real worldwide increase in the elderly population. Special emphasis has been placed on the management of hypertension in the geriatric patient, since its long-term benefits have been shown to prevent both cerebral and cardiac infarctions. Calcium channel blockers have been shown to be effective in this condition in the elderly. Their success depends on their mechanism of action, as well as on the physiological changes observed, and on the aging process itself, which include cardiac hypertrophy, calcification of cardiac valves, and a decrease in the excitation-conduction system. There is thickening of the tunica intima of the arteries, and the production of nitric oxide at cellular level decreases with age, along with an increase in endothelin 1, which leads to vascular endothelium dysfunction. In the kidneys, there is a decrease in prostacyclin, endothelial hyperpolarization factor, as well as the Klotho anti-aging protein, which leads to an increase in blood pressure. Calcium channel blocker drugs have been shown to be effective in any age group for the management of hypertension, and are safe in the el...Continue Reading

Citations

Jan 26, 2017·Journal of Cellular Physiology·Yi ShengRui Xiao
Jul 30, 2020·Investigative Ophthalmology & Visual Science·Qingsheng PengXiaohong Yang
Nov 14, 2018·Biochemical Society Transactions·Sujeevi S K NawaratnaGeoffrey N Gobert
Nov 20, 2019·International Journal of Molecular Sciences·Armand JaminonLeon Schurgers
Mar 19, 2019·Expert Opinion on Drug Metabolism & Toxicology·L E J PeetersJ Versmissen

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