Calcium channel blockers increase the amount of nitrite production in rabbits without decreasing the responsiveness of platelets to collagen

Clinical and Experimental Medicine
B SirmagülK Erol

Abstract

By virtue of their ability to increase nitric oxide (NO) production, it is thought that calcium channel blockers (CCBs) may be involved in the inhibition of platelet aggregation. In an attempt to compare the abilities of different groups of calcium antagonists to affect NO generation and platelet aggregation, single doses of the calcium antagonists verapamil, nicardipine and diltiazem were administered to rabbits. It was found that each of these drugs increased the levels of nitrite significantly. It was also found that these drugs had different time courses of action. Of the CCBs used in this study, verapamil was found to induce the greatest increase in nitrite production (about a 4-fold increase over basal levels), peaking at 90 min (P<0.001). Diltiazem and nicardipine (3.5-fold and 2.5-fold increase over basal levels, respectively) were both found to induce increases in NO which peaked at 150 min (P<0.001 and P<0.01 respectively). Each of the drugs was then given at double the original dose; however, nicardipine was the only drug that was seen to further increase nitrite production (P<0.001). Blood samples taken from the animals were analysed using whole-blood aggregometry in order to assess the amount of collagen-induced pl...Continue Reading

References

Jul 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·M W RadomskiS Moncada
Jan 23, 1992·The New England Journal of Medicine·V FusterJ H Chesebro
Nov 1, 1991·Prostaglandins, Leukotrienes, and Essential Fatty Acids·G AnfossiG Emanuelli
Jan 1, 1990·Annual Review of Physiology·T J Rink, S O Sage
Jun 1, 1990·Biochemical Medicine and Metabolic Biology·G H RaoJ G White
Jun 1, 1986·British Journal of Pharmacology·H AzumaS Sekizaki
Nov 1, 1984·Clinical Pharmacology and Therapeutics·K F CremerJ Mehta
Oct 1, 1982·Analytical Biochemistry·L C GreenS R Tannenbaum
May 1, 1994·Journal of Cardiac Surgery·G Welch, J Loscalzo
Mar 1, 1994·Trends in Pharmacological Sciences·C FasolatoT Pozzan
Feb 9, 1996·The Journal of Biological Chemistry·A B MacKenzieS O Sage
Feb 20, 1996·Proceedings of the National Academy of Sciences of the United States of America·M A MoroS Moncada
Jan 1, 1997·European Heart Journal·P Hjemdahl, N H Wallén
Mar 22, 1997·Lancet·P ForteN Benjamin
May 5, 2001·American Journal of Hypertension·A CamillettiL Mazzanti
Oct 18, 2001·Current Opinion in Hematology·B SavageZ M Ruggeri
Oct 31, 2002·Vascular Pharmacology·J P De La CruzF Sánchez de la Cuesta
Apr 15, 2003·Toxicology and Applied Pharmacology·Tsung-Ming ShihJohn H McDonough
Sep 19, 2003·Vascular Pharmacology·Adrian J Hobbs, Salvador Moncada
Dec 9, 2003·European Heart Journal·Andrew D BlannGregory Y H Lip
Nov 2, 2004·Progress in Cardiovascular Diseases·Ehud Grossman, Franz H Messerli

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Citations

Feb 16, 2013·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Chung-Hun OhYun-Hee Rhee
Feb 28, 2020·Oxidative Medicine and Cellular Longevity·Jelena RisticVladimir Jakovljevic

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