Calcium channels as target sites of heavy metals

Toxicology Letters
D Büsselberg

Abstract

Zinc (Zn), aluminium (Al), mercury (Hg), methylmercury (MeHg) and lead (Pb) extracellulary applied reduce voltage-activated calcium channel currents (VACCCs); Pb and Al also reduce N-methyl-D-aspartate (NMDA)-activated channel currents (NACCs). Pb is most effective in reducing VACCCs, with an IC50 of 0.46 microM, followed by Hg (IC50 = 1.1 microM) and MeHg (IC50 = 2.6 microM). Zn and Al were less potent (IC50 = 69 and 84 microM, respectively). Al acts on channels in the open state; its effect is pH dependent. The effects of Pb were specific for VACCCs and NACCs. Hg, Al and Zn had only minor effects on voltage-activated potassium and sodium channels, while MeHg reduced potassium channel currents (IC50 = 2.2 microM) and, at higher concentrations, sodium channel currents (IC50 = 12.3 microM). Al also reduced other receptor-activated channel currents. These results demonstrate that a variety of metal species produce different actions at the level of the cell membrane.

References

Dec 1, 1994·Cellular and Molecular Neurobiology·D BüsselbergB Platt
Dec 1, 1994·Cellular and Molecular Neurobiology·B Platt, D Büsselberg
Dec 1, 1994·Cellular and Molecular Neurobiology·B Platt, D Büsselberg
Feb 1, 1993·Naunyn-Schmiedeberg's Archives of Pharmacology·V UteshevH L Haas

❮ Previous
Next ❯

Citations

Sep 21, 2001·Journal of Neuroscience Methods·E VareaC Lopez-Garcia
May 23, 1998·Annual Review of Pharmacology and Toxicology·L G Costa
Nov 20, 2012·Journal of Human Reproductive Sciences·Serah F Ige, Roland E Akhigbe
Apr 16, 1998·Environmental Health Perspectives·M A PerazaL T Rael
Jan 14, 1998·Brain Research. Developmental Brain Research·J V Sanchez-AndresC Lopez-Gracia
Jun 7, 2011·Neurotoxicology and Teratology·William H DribbenNuri Farber
Mar 16, 2011·Toxicology Letters·Patrícia ReckziegelMarilise Escobar Bürger
Jul 27, 2011·Environmental Toxicology and Pharmacology·Gábor OszláncziAndrás Papp
Oct 6, 2009·Physiology & Behavior·Helmut V B HirschBernard Possidente
May 26, 2009·Neurotoxicology·Ana-Maria Florea, Dietrich Büsselberg
Jul 23, 2008·Neurotoxicology·Anke Tomaszewski, Dietrich Büsselberg
Aug 23, 2008·Journal of Basic Microbiology·Joseph LemireVasu D Appanna
Sep 2, 2006·Neurotoxicology·Anke Tomaszewski, Dietrich Büsselberg
Aug 4, 2001·Toxicology and Applied Pharmacology·J S Fedan, D Cutler
Aug 11, 2000·Toxicology and Applied Pharmacology·J E Sirois, W D Atchison
Oct 21, 1999·Toxicology and Applied Pharmacology·K SalnikowM Costa
Aug 19, 2016·Environmental Science and Pollution Research International·Mikołaj KaczmarskiWioletta Sośnicka
Aug 11, 2004·Toxicology Letters·Zhigang David Luo, Harvey Alan Berman
Sep 5, 2002·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Alexandra H HeussnerDaniel R Dietrich
Jul 15, 2006·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Ana-Maria Florea, Dietrich Büsselberg
Dec 30, 2014·Archives of Environmental Contamination and Toxicology·Tamzin A Blewett, Chris M Wood
Dec 19, 2012·Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering·Zuzana KnazickaPeter Massanyi
Dec 8, 2020·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Ab Latif WaniMohammad Afzal
Feb 3, 2021·Toxics·Daniela Ramírez OrtegaVerónica Pérez de la Cruz
Mar 27, 2009·The Journal of Physical Chemistry. B·Marcin Broniatowski, Patrycja Dynarowicz-Łatka
Aug 7, 2007·Journal of Inorganic Biochemistry·Paula P Gonçalves, Virgília S Silva

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
Ana-Maria Florea, D Büsselberg
The Journal of Experimental Biology
Nicolas R BuryChris N Glover
© 2021 Meta ULC. All rights reserved