Calcium currents in striatal fast-spiking interneurons: dopaminergic modulation of CaV 1 channels

BMC Neuroscience
Ernesto Alberto Rendón-OchoaJ Bargas

Abstract

Striatal fast-spiking interneurons (FSI) are a subset of GABAergic cells that express calcium-binding protein parvalbumin (PV). They provide feed-forward inhibition to striatal projection neurons (SPNs), receive cortical, thalamic and dopaminergic inputs and are coupled together by electrical and chemical synapses, being important components of the striatal circuitry. It is known that dopamine (DA) depolarizes FSI via D1-class DA receptors, but no studies about the ionic mechanism of this action have been reported. Here we ask about the ion channels that are the effectors of DA actions. This work studies their Ca2+ currents. Whole-cell recordings in acutely dissociated and identified FSI from PV-Cre transgenic mice were used to show that FSI express an array of voltage gated Ca2+ channel classes: CaV1, CaV2.1, CaV2.2, CaV2.3 and CaV3. However, CaV1 Ca2+ channel carries most of the whole-cell Ca2+ current in FSI. Activation of D1-like class of DA receptors by the D1-receptor selective agonist SKF-81297 (SKF) enhances whole-cell Ca2+ currents through CaV1 channels modulation. A previous block of CaV1 channels with nicardipine occludes the action of the DA-agonist, suggesting that no other Ca2+ channel is modulated by D1-receptor ...Continue Reading

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Citations

Jan 5, 2020·The European Journal of Neuroscience·Mariana DuhneJosé Bargas
Apr 18, 2021·Progress in Neuro-psychopharmacology & Biological Psychiatry·Dipashree ChatterjeeRobert Gerlai
Dec 16, 2020·ACS Biomaterials Science & Engineering·Kenneth NdyabaweWilliam S Kisaalita

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