PMID: 8606339Jan 1, 1995Paper

Calcium dependence of alpha-aminoisobutyric acid transfer in human bilaterally perfused placental lobules

Journal of Perinatal Medicine
B R KrishnaS P Brennecke

Abstract

Human isolated bilaterally perfused placental lobules were employed to study the Ca++ dependence of materno-fetal transfer of the non-metabolisable amino acid, alpha-aminoisobutyric acid (AIB). Bilateral perfusion with Ca(++)-free Krebs' solution containing 2 mmol/l EDTA for 60 min resulted in a significant reduction in materno-fetal AIB transfer compared to controls perfused with normal Krebs' solution. However, bilateral perfusion with Krebs' solution containing: 2.5 mmol/l Ca++ and 2 mmol/l EDTA; 3.8 mmol/l Ca++ with no EDTA; or Ca(++)-free Krebs' solution alone did not produce significantly different materno-fetal AIB transfer compared to placentae perfused with normal Krebs' solution. The reduction in AIB transfer during perfusion with Ca(++)-free Krebs' solution with EDTA was partially restored with subsequent reperfusion with normal Krebs' solution for 90 min. These results suggest that AIB transfer in human perfused placental lobules is at least partially Ca(++)-dependent.

References

Jan 1, 1991·Reproduction, Fertility, and Development·B R KrishnaS P Brennecke
Jan 1, 1990·Reproduction, Fertility, and Development·B R KrishnaS P Brennecke
Jan 29, 1990·Biochimica Et Biophysica Acta·Y Kudo, C A Boyd
Jan 1, 1988·Pediatric Research·P I KarlS E Fisher
Sep 1, 1988·Clinical and Experimental Pharmacology & Physiology·S P BrenneckeA L Boura
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Apr 1, 1972·The American Journal of Roentgenology, Radium Therapy, and Nuclear Medicine·B DamascelliR Saccozzi
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Citations

May 27, 2003·The Journal of Physiology·L H ClarsonT Powell
Oct 25, 2016·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Misato UrakiMasahiro Iwaki

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