Calcium dependence of ryanodine-sensitive calcium channels from brain cortex endoplasmic reticulum

FEBS Letters
J J MarengoCecilia Hidalgo

Abstract

Endoplasmic reticulum vesicles isolated from rat brain cortex and fused with lipid bilayers displayed ryanodine-sensitive calcium channels, with three cytoplasmic calcium dependences. A: Channels (n=5) stimulated by Ca2+ (K0.5=1.2 microM and nHill=1.9) and not inhibited up to 0.5 mM Ca2+. B: Channels (n=14) cooperatively activated (K0.5=6.9 microM and nHill=1.8), and inhibited by Ca2+ (K0.5=152 microM and nHill=1.8). C: Low Po (<0.1) channels (n=22), non-cooperatively activated and inhibited with the same K0.5=26.3 microM Ca2+. These three types of responses to cytoplasmic [Ca2+] may underlie separate calcium release pathways in neurons of rat brain cortex.

References

Sep 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·H TowbinJ Gordon
Dec 1, 1992·The Biochemical Journal·F A LaiG Meissner
Mar 1, 1990·Biophysical Journal·M FillC F Louis
Sep 1, 1987·The American Journal of Physiology·E RousseauG Meissner
Nov 1, 1989·Trends in Neurosciences·M B Kennedy
Apr 1, 1983·Pflügers Archiv : European journal of physiology·E JaimovichO Rougier
Jul 1, 1995·Medicinal Research Reviews·G Giannini, V Sorrentino
Nov 1, 1994·Biophysical Journal·A L PercivalJ L Sutko
Jun 8, 1993·Biochemistry·J A AireyD Witcher
Nov 1, 1994·Neuroscience·P Kostyuk, A Verkhratsky
Jun 1, 1994·The American Journal of Physiology·R CoronadoD M Vaughan
Sep 1, 1995·The Journal of Membrane Biology·D R LaverA F Dulhunty

❮ Previous
Next ❯

Citations

Feb 11, 1999·Pharmacology, Biochemistry, and Behavior·F L SmithW L Dewey
Dec 3, 2005·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Cecilia Hidalgo
Jan 15, 2014·Journal of Molecular and Cellular Cardiology·Paulina DonosoRicardo Bull
Mar 16, 2007·American Journal of Physiology. Cell Physiology·Ricardo BullCecilia Hidalgo
Mar 15, 2003·American Journal of Physiology. Cell Physiology·Ricardo BullOsvaldo Alvarez
May 15, 2003·The Journal of Biological Chemistry·Nael Nadif KasriHumbert De Smedt
Mar 5, 1998·The American Journal of Physiology·K E QuinnB E Ehrlich

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.