Calcium-dependent adhesion is necessary for the maintenance of prosomeres

Developmental Biology
M M McCarthyG Fishell

Abstract

Cell adhesion has been suggested to function in the establishment and maintenance of the segmental organization of the central nervous system. Here we tested the role of different classes of adhesion molecules in prosencephalic segmentation. Specifically, we examined the ability of progenitors from different prosomeres to reintegrate and differentiate within various brain regions after selective maintenance or removal of different classes of calcium-dependent versus -independent surface molecules. This analysis implicates calcium-dependent adhesion molecules as central to the maintenance of prosomeres. Only conditions that spared calcium-dependent adhesion systems but ablated more general (calcium-independent) adhesion systems resulted in prosomere-specific integration after transplantation. Among the members of this class of adhesion molecules, R-cadherin shows a striking pattern of prosomeric expression during development. To test whether expression of this molecule was sufficient to direct progenitor integration to prosomeres expressing R-cadherin, we used a retroviral-mediated gain-of-function approach. We found that progenitors originally isolated from prosomere P2 (a region which does not express R-cadherin), when forced ...Continue Reading

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Dec 18, 2001·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·C Redies, L Puelles
Jan 7, 2004·Journal of Physiology, Paris·Christoph RediesJiankai Luo
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Dec 16, 2020·The Journal of Comparative Neurology·Rio IkutaMami Kurumata-Shigeto

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