PMID: 142838Aug 4, 1977

Calcium dependent ATP losses in intact red blood cells without cellular accumulations of calcium

The Journal of Membrane Biology
G A Plishker, H J Gitelman


Intact human red blood cells incubated with ionophore A23187 and calcium develop a depletion of ATP that is dependent upon the concentrations of both A23187 and Ca. Incubations of fresh cells with 0.5 micrometer A23187 and concentrations of Ca at or below 70 micrometer produce a depletion of ATP without a net cellular uptake of Ca. In contrast, ATP-depleted cells display an ionophore-dependent cellular uptake of Ca, under identical conditions. A hypothesis is proposed that relates these ionophore-produced ATP depletions to active Ca extrusion by the Ca ATPase.


Jan 1, 1975·The Journal of General Physiology·J C ParkerD L Leonard
Jun 15, 1975·Experientia·F H KirkpatrickP L La Celle
Oct 1, 1970·Analytical Biochemistry·L Dufresne, H J Gitelman
Jul 1, 1971·The American Journal of Physiology·J C Parker
Jul 1, 1961·Clinica Chimica Acta; International Journal of Clinical Chemistry·E van KAMPEN, W G ZIJLSTRA


Jan 1, 1982·Pharmacology & Therapeutics·J S Wiley, K E McCulloch
Feb 1, 1981·The Journal of Clinical Investigation·M R ClarkS B Shohet
Oct 7, 1982·Biochimica Et Biophysica Acta·E A O'RearE C Lynch
Sep 30, 1980·Biochimica Et Biophysica Acta·B Sarkadi
Jan 1, 1983·Annals of the New York Academy of Sciences·F J Nordt
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