PMID: 11328457May 1, 2001Paper

Calcium-dependent effects of melatonin inhibition of glutamatergic response in rat striatum

Journal of Neuroendocrinology
G EscamesDarío Acuña-Castroviejo

Abstract

The effects of melatonin, amlodipine, diltiazem (L-type Ca2+ channel blockers) and omega-conotoxin (N-type Ca2+ channel blocker) on the glutamate-dependent excitatory response of striatal neurones to sensory-motor cortex stimulation was studied in a total of 111 neurones. Iontophoresis of melatonin produced a significant attenuation of the excitatory response in 85.2% of the neurones with a latency period of 2 min. Iontophoresis of either L- or N-type Ca2+ channel blocker also produced a significant attenuation of the excitatory response in more than 50% of the recorded neurones without significant latency. The simultaneous iontophoresis of melatonin + amlodipine or melatonin + diltiazem did not increase the attenuation produced by melatonin alone. However, the attenuation of the excitatory response was significantly higher after ejecting melatonin + omega-conotoxin than after ejecting melatonin alone. The melatonin-Ca2+ relationship was further supported by iontophoresis of the Ca2+ ionophore A-23187, which suppressed the inhibitory effect of either melatonin or Ca2+ antagonists. In addition, in synaptosomes prepared from rat striatum, melatonin produced a decrease in the Ca2+ influx measured by Fura-2AM fluorescence. Binding ...Continue Reading

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Citations

Dec 25, 2004·Journal of Pineal Research·Josefa LeónRussel J Reiter
May 10, 2006·Journal of Endocrinological Investigation·S AydoganA Goktas
Feb 21, 2014·Cellular and Molecular Life Sciences : CMLS·Darío Acuña-CastroviejoRussel J Reiter
Dec 9, 2004·Journal of Neuroendocrinology·G EscamesD Acuña-Castroviejo
Apr 7, 2004·Journal of Pineal Research·Leila BikjdaoueneDarío Acuña-Castroviejo
Jun 26, 2003·Journal of Pineal Research·Leila BikjdaoueneDarío Acuña-Castroviejo
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Feb 5, 2021·Antioxidants·Maria-Angeles Bonmati-Carrion, Antonia Tomas-Loba
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Jul 3, 2021·International Journal of Molecular Sciences·Jaydeep RoyLee Wei Lim

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