Calcium-dependent epidermal growth factor receptor transactivation mediates the angiotensin II-induced mitogen-activated protein kinase activation in vascular smooth muscle cells.

The Journal of Biological Chemistry
S EguchiT Inagami

Abstract

We have recently reported that angiotensin II (Ang II)-induced mitogen-activated protein kinase (MAPK) activation is mainly mediated by Ca2+-dependent activation of a protein tyrosine kinase through Gq-coupled Ang II type 1 receptor in cultured rat vascular smooth muscle cells (VSMC). In the present study, we found Ang II rapidly induced the tyrosine phosphorylation of the epidermal growth factor (EGF) receptor and its association with Shc and Grb2. These reactions were inhibited by the EGF receptor kinase inhibitor, AG1478. The Ang II-induced phosphorylation of the EGF receptor was mimicked by a Ca2+ ionophore and completely inhibited by an intracellular Ca2+ chelator. Thus, AG1478 abolished the MAPK activation induced by Ang II, a Ca2+ ionophore as well as EGF but not by a phorbol ester or platelet-derived growth factor-BB in the VSMC. Moreover, Ang II induced association of EGF receptor with catalytically active c-Src. This reaction was not affected by AG1478. These data indicate that Ang II induces Ca2+-dependent transactivation of the EGF receptor which serves as a scaffold for pre-activated c-Src and for downstream adaptors, leading to MAPK activation in VSMC.

References

Sep 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·Y ZhaoJ Krueger
Oct 15, 1992·Biochemical and Biophysical Research Communications·J L DuffM A Corson
Oct 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·J McGladeT Pawson
Oct 1, 1990·Molecular and Cellular Biology·A J NaftilanA S Kraft
Jan 4, 1994·Proceedings of the National Academy of Sciences of the United States of America·D K LuttrellT M Gilmer
Feb 16, 1995·Nature·T Pawson
Mar 10, 1995·The Journal of Biological Chemistry·E Giasson, S Meloche
Dec 1, 1995·Circulation Research·M IshidaB C Berk
Jun 23, 1995·The Journal of Biological Chemistry·M H Cobb, E J Goldsmith
Jan 1, 1994·Annual Review of Cell Biology·P van der GeerR A Lindberg
Mar 24, 1995·Science·A Levitzki, A Gazit
Feb 1, 1994·Current Opinion in Genetics & Development·J Schlessinger
Jul 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·J Blenis
Jun 1, 1993·Circulation Research·W SchorbK M Baker
Feb 6, 1996·Proceedings of the National Academy of Sciences of the United States of America·L B Rosen, M E Greenberg
Mar 8, 1996·The Journal of Biological Chemistry·H KawakatsuJ Yano
Apr 26, 1996·The Journal of Biological Chemistry·B SchiefferK E Bernstein
Jun 20, 1996·The New England Journal of Medicine·T L GoodfriendK J Catt
Jan 1, 1997·Hypertension·K K GriendlingR W Alexander

❮ Previous
Next ❯

Citations

Feb 20, 2002·Journal of Molecular and Cellular Cardiology·Hiroaki KodamaSatoshi Ogawa
Feb 9, 2008·Cellular and Molecular Life Sciences : CMLS·M J Wieduwilt, M M Moasser
May 1, 2012·Pflügers Archiv : European journal of physiology·Manne KropMarcel E Meima
Jun 9, 2005·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Ihor V Yosypiv, Samir S El-Dahr
Jan 28, 2012·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Hua LiaoXiaomei Guo
Mar 9, 2002·Current Hypertension Reports·Yuji Saito, Bradford C Berk
Jan 27, 2004·Biochemical and Biophysical Research Communications·T YonezawaY Obara
Jun 21, 2002·Biochemical and Biophysical Research Communications·Shuichi SaitoSatoru Eguchi
Jun 4, 1999·Progress in Biophysics and Molecular Biology·M H Cobb
Nov 30, 1999·Trends in Pharmacological Sciences·E ZwickA Ullrich
Sep 1, 2000·Regulatory Peptides·K K Griendling, M Ushio-Fukai
Feb 4, 1999·Regulatory Peptides·W G Thomas
Mar 20, 2003·Molecular and Cellular Endocrinology·Susan A HobsonKarin D Rodland
Apr 18, 2002·Free Radical Biology & Medicine·Waleed N HassanK Eric Paulson
Oct 25, 2003·Cellular Signalling·Raymond E Menard, Raymond R Mattingly
Apr 21, 1999·Current Opinion in Cell Biology·L M LuttrellR J Lefkowitz
Apr 5, 2003·The International Journal of Biochemistry & Cell Biology·Guoyong YinBradford C Berk
Aug 26, 2000·Cytokine & Growth Factor Reviews·R Iwamoto, E Mekada
Dec 26, 2001·Cytokine & Growth Factor Reviews·Francis S LeeMoses V Chao
Oct 20, 2001·Cell Research·D F GuoT Inagami
May 15, 2007·Oncogene·Z G Goldsmith, D N Dhanasekaran
Aug 19, 2000·The Biochemical Journal·L del Carmen MedinaJ A García-Sáinz
Dec 11, 2002·Journal of Neurochemistry·Hitoshi NakayamaToshihiko Ikeuchi
Jul 27, 2001·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·K RodgersG Dizerega
Apr 13, 2011·Proceedings of the National Academy of Sciences of the United States of America·Jody L SwiftJean-Martin Beaulieu
Nov 26, 2010·The Journal of Biological Chemistry·Rafal Robert NazarewiczR Wayne Alexander

❮ Previous
Next ❯

Related Concepts

Related Feeds

ASBMB Publications

The American Society for Biochemistry and Molecular Biology (ASBMB) includes the Journal of Biological Chemistry, Molecular & Cellular Proteomics, and the Journal of Lipid Research. Discover the latest research from ASBMB here.