PMID: 8592186Nov 1, 1995Paper

Calcium-dependent plateau potentials in a crab stomatogastric ganglion motor neuron. I. Calcium current and its modulation by serotonin

Journal of Neurophysiology
B Zhang, R M Harris-Warrick

Abstract

1. Using current- and voltage-clamp techniques, we examined the biophysical properties of a voltage-dependent Ca2+ current and its physiological role in plateau potential generation in the dorsal gastric (DG) motor neuron of the stomatogastric ganglion in the crab, Cancer borealis. 2. Stimulation of one of a set of identified serotonergic/cholinergic mechanosensory cells, the gastropyloric receptor (GPR) cells, induced plateau potentials in DG. A brief pressure application of serotonin (5-HT) closely mimicked the effect of the GPR cells. The 5-HT-evoked plateau in DG was not blocked by the sodium channel blocker, tetrodotoxin (TTX), or a combination of TTX with potassium channel blockers, including tetraethylammonium (TEA) and 4-aminopyridine (4-AP), and the Ih blocker, CsCl. The 5-HT-evoked plateau was eliminated by the Ca2+ channel blockers Co2+ and Cd2+, suggesting that Ca2+ entry is essential for plateau potentials in DG. During the plateau, we observed a 30% decrease in input resistance. 3. When sodium and potassium currents were blocked pharmacologically, injection of suprathreshold depolarizing current evoked all-or-none plateau-like responses lasting several seconds, even in the absence of 5-HT. This response was blocke...Continue Reading

Citations

May 30, 1998·Journal of Neurophysiology·L M Hurley, K Graubard
Aug 15, 1998·Journal of Neurophysiology·R H Lee, C J Heckman
Jun 26, 2009·Proceedings of the National Academy of Sciences of the United States of America·Rachel GrashowEve Marder
Jul 11, 2006·Journal of Neurophysiology·Sarah M Jones, Robert H Lee
Oct 16, 2009·Journal of Neurophysiology·Alan K H TamNeil S Magoski
Jun 23, 2009·Nature Reviews. Neuroscience·Martyn Goulding
Mar 27, 2009·Nature Neuroscience·Shawn R Lockery, Miriam B Goodman
Feb 14, 2018·The Journal of Experimental Biology·Gáspár JékelyLindy Holden-Dye
Aug 9, 2003·Journal of Neurophysiology·Bruce R JohnsonRonald M Harris-Warrick
Nov 18, 2005·Journal of Neurophysiology·Thuc LeJohn T Birmingham
Mar 3, 1999·Proceedings of the National Academy of Sciences of the United States of America·R HeinrichE A Kravitz
Oct 14, 2009·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Wolfgang Stein
Feb 7, 1998·Journal of Neurophysiology·B R Johnson, R M Harris-Warrick
Apr 20, 2005·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·James D AngstadtSarah M Levasseur

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