PMID: 8592187Nov 1, 1995Paper

Calcium-dependent plateau potentials in a crab stomatogastric ganglion motor neuron. II. Calcium-activated slow inward current

Journal of Neurophysiology
B ZhangR M Harris-Warrick

Abstract

1. Using intracellular recording and voltage-clamp techniques, we examined the biophysical properties of a Ca(2+)-activated slow inward current and its physiological role in plateau potential generation in the dorsal gastric (DG) motor neuron of the stomatogastric ganglion in the crab, Cancer borealis. 2. As shown in the accompanying paper, a brief puff of serotonin (5-HT) evoked a plateau potential in the DG neuron. Intracellular loading of the Ca2+ chelator ethylene glycol-bis (beta-aminoethyl ether)-N,N,N',N'-tetraacetic acid (EGTA) prevented 5-HT from evoking a plateau potential. On the contrary, rapid increase of intracellular Ca2+ by photolysis of caged-Ca2+ (bound to DM-nitrophen) evoked a plateau response in DG bathed in normal saline. 3. Extracellular tetrodotoxin (TTX), tetraethylammonium (TEA), 4-aminopyridine (4-AP), and Cs+ and intracellular iontophoresis of Cs+ were used to block voltage-dependent INa, IK, and Ih. Under these conditions we voltage clamped DG using two electrodes and isolated a long-lasting tail current after a short depolarization of the cell. 4. The reversal potential of the slow tail current was extrapolated to be -27 +/- 3.5 (SE) mV. Na+ substitutions with choline+, tris(hydroxymethyl)aminometh...Continue Reading

Citations

Nov 18, 2005·Journal of Neurophysiology·Thuc LeJohn T Birmingham
Jun 10, 2006·The Journal of Physiology·Derek A Lupinsky, Neil S Magoski
Jul 11, 2006·Journal of Neurophysiology·Sarah M Jones, Robert H Lee
Oct 16, 2009·Journal of Neurophysiology·Alan K H TamNeil S Magoski
Sep 4, 2015·Physiology·Aklesso KadalaArlette Kolta
Aug 13, 1999·Journal of Neurophysiology·J F Perrier, J Hounsgaard
Sep 1, 2006·Journal of Neurophysiology·Rafael Levi, Allen I Selverston
Aug 24, 2007·Journal of Neurophysiology·Ryoichi Teruyama, William E Armstrong
Jun 26, 2009·Proceedings of the National Academy of Sciences of the United States of America·Rachel GrashowEve Marder
May 30, 1998·Journal of Neurophysiology·L M Hurley, K Graubard
Apr 20, 2005·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·James D AngstadtSarah M Levasseur
Oct 14, 2009·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Wolfgang Stein
Jun 17, 2011·Journal of Neurophysiology·Lolahon R KadiriRonald M Harris-Warrick
Jun 1, 2014·The Journal of Physiology·T S AlvaresG D Funk
May 13, 2017·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·James D AngstadtAlexander J Goncalves
Aug 7, 2002·Journal of Neurophysiology·Fu-Sun Lo, Reha S Erzurumlu
Aug 9, 2003·Journal of Neurophysiology·Bruce R JohnsonRonald M Harris-Warrick

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.