Calcium-dependent signaling mechanisms and soleus fiber remodeling under gravitational unloading.

Journal of Muscle Research and Cell Motility
B S Shenkman, T L Nemirovskaya

Abstract

The decrease in postural muscle fiber size, diminishing of their contractile properties, slow-to-fast shift in myosin heavy chain expression pattern are known to be the main consequences of gravitational unloading. The Ca(2+) role in these processes has been studied for about 20 years. Ingalls et al. [J Appl Physiol 87(1):382-390, 1999] found the resting Ca(2+) level increase in soleus fibers of hindlimb unloaded mice. Results obtained in our laboratory showed that systemic or local application of nifedipine (L-type Ca(2+) channels' blocker) prevents Ca(2+) accumulation in fibers. Thus, activation of dihydropyridine calcium channels can be supposed to promote resting Ca(2+) loading under disuse. So, calcium-dependent signaling pathways may play an important role in the development of some key events observed under unloading. Since 90th the increased activities of Ca(2+)-dependent proteases (calpains) were considered as the crucial effect of hypogravity-induced muscle atrophy, which was proved later. We observed maintenance of titin and nebulin relative content in soleus muscle under unloading combined with Ca(2+) chelators administration. Nifedipine administration was shown to considerably restrict the slow-to-fast transition o...Continue Reading

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