PMID: 2502772Jun 1, 1989Paper

Calcium-dependent slow outward current in visceral primary afferent neurones of the rabbit

Pflügers Archiv : European journal of physiology
K Morita, Y Katayama

Abstract

Slow outward currents were recorded from voltage-clamped neurones in nodose ganglia excised from rabbits. In the majority of Type C neurones, a short depolarizing command pulse evoked a slow outward tail current (ISAH) with a decay time constant ranging from 0.5 to 2 s. The ISAH was due to an increase in membrane conductance to K+ because its reversal potential was approximately equal to the Nernst potential for K+. The ISAH was reversibly blocked by removal of external Ca2+ or by Ca2+ antagonists. A Ca2+ ionophore, A23187, produced an outward current which was similar to the ISAH. The ISAH was resistant to tetraethylammonium and depressed by Ba2+, whereas it was not affected by Cs+ and 4-aminopyridine. The ISAH was initially augmented and subsequently depressed by apamin (1-10 nM) and (+)-tubocurarine (100-600 microM). It is concluded that the ISAH in visceral primary neurones may be due to a long-lasting increase in K+ conductance caused by an increase in the concentration of intracellular Ca2+, resulting from Ca2+ entry during the depolarizing command pulse.

References

Jan 1, 1978·Annual Review of Biophysics and Bioengineering·R W Meech
Nov 1, 1979·The Journal of Physiology·A L Gorman, A Hermann
Mar 1, 1986·Journal of Neurophysiology·S R IkedaF F Weight
Apr 1, 1985·The Journal of Physiology·G D HirstD F van Helden
Apr 1, 1985·The Journal of Physiology·G D HirstD F van Helden
May 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·P PennefatherR A Nicoll
Jan 1, 1986·British Journal of Pharmacology·T Kawai, M Watanabe
Mar 1, 1974·The Journal of Physiology·R W Meech
Nov 1, 1984·The Journal of Physiology·M Galvan, C Sedlmeir
Jun 1, 1980·The Journal of General Physiology·D C Eaton, M S Brodwick
Jan 1, 1981·Annual Review of Neuroscience·S Hagiwara, L Byerly
Jul 1, 1981·The Journal of General Physiology·A Hermann, A L Gorman
Oct 1, 1982·The Journal of Physiology·J N BarrettB S Pallotta
Dec 1, 1983·Journal of Neurophysiology·J E Freschi
Nov 1, 1983·Pflügers Archiv : European journal of physiology·K KubaM Nohmi
Oct 1, 1984·The Journal of Physiology·H HigashiR A North
Sep 1, 1983·The Journal of Physiology·C Belmonte, R Gallego
Apr 1, 1983·The Journal of Physiology·D A Brown, W H Griffith
Aug 1, 1982·Pflügers Archiv : European journal of physiology·H Ito
Aug 1, 1982·The Journal of Physiology·K MoritaT Tokimasa
Nov 1, 1980·The Journal of Physiology·A L Gorman, M V Thomas

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