Calcium dobesilate attenuates vascular injury and the progression of diabetic retinopathy in streptozotocin-induced diabetic rats

Diabetes/metabolism Research and Reviews
Eugenia PadillaT Tejerina

Abstract

Diabetic retinopathy (DR) is a highly specific vascular complication of type 1 and type 2 diabetes mellitus. Calcium dobesilate (DOBE) has been tested in the treatment of diabetic retinopathy showing a slowdown of the progression of the disease after long-term oral treatment. The aim of this study was to determine the effects of DOBE on vascular and diabetic retinopathy in streptozotocin (STZ) diabetic rats. Diabetes was induced in wistar rats by the administration of STZ (60 mg/kg, i.p.). Rats were divided into three groups (n = 30). Group 0 (GO): nondiabetic rats. Group 1 (G1): 14 months of insulin treatment after diabetes development. Group 2 (G2): 14 months of insulin treatment after diabetes development plus DOBE (500 mg/kg/day). At the end of the treatment, vascular reactivity was tested. The study of the vascularization of the retina was performed on wholemounts of trypsin retinal digest preparations and retinal sections. Relaxation induced by acetylcholine decreased in the aorta arteries from diabetic rats but it was restored to control values in the DOBE-treated group (71.8 +/- 4.5%, 53.3 +/- 0.5%, 67.4 +/- 4.6% in group 0, 1 and 2 respectively). DOBE treatment also restored noradrenaline (1.08 +/- 0.05 g, 1.70 +/- 0.0...Continue Reading

References

Jul 1, 1979·The Journal of General Physiology·M J Mulvany, D M Warshaw
Aug 25, 1992·European Journal of Pharmacology·T TejerinaJ Tamargo
Mar 1, 1990·International Ophthalmology·E B LeiteJ G Cunha-Vaz
Aug 9, 1988·European Journal of Pharmacology·K H Harris, K M MacLeod
Apr 20, 1989·The New England Journal of Medicine·I Saenz de TejadaR A Cohen
Jun 1, 1988·British Journal of Pharmacology·W DuranteF A Sunahara
Jan 1, 1985·Canadian Journal of Physiology and Pharmacology·K M MacLeod, J H McNeill
Mar 29, 1988·European Journal of Pharmacology·T TejerinaJ Tamargo
Dec 2, 1986·European Journal of Pharmacology·Y OyamaM Kanno
Jan 1, 1974·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·H Freyler
Oct 1, 1967·Proceedings of the Society for Experimental Biology and Medicine·A JunodA E Renold
May 5, 1998·Fundamental & Clinical Pharmacology·J BrunetP Hannaert
Jul 14, 1998·Journal of Toxicology and Environmental Health. Part a·N H AnsariA Mansour
Oct 17, 1998·British Journal of Pharmacology·E Ruiz, T Tejerina
Dec 8, 1998·The International Journal of Angiology : Official Publication of the International College of Angiology, Inc·T TejerinaP Ganado
Feb 10, 2000·The New England Journal of Medicine·UNKNOWN Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Research GroupDavid M Nathan
Apr 15, 2000·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·E N SuK Yogesan
Dec 1, 1960·Archives of Ophthalmology·T KUWABARA, D G COGAN
Nov 25, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Dacia L HuntonRichard B Marchase

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Brain Barrier

The blood brain barrier is a border that separates blood from cerebrospinal fluid. Discover the latest search on this highly selective semipermeable membrane here.