PMID: 9180351Jan 1, 1997Paper

Calcium dynamics in cultured heart cells exposed to defibrillator-type electric shocks

Life Sciences
V Krauthamer, J L Jones

Abstract

Spatial and temporal changes in intracellular calcium ion concentration and transmembrane voltage were recorded optically from single-isolated cultured chick-embryo heart cells exposed to high-voltage, defibrillator-type shocks. Fluorescence changes were measured during 5 msec electric shocks of field strengths up to 56 volts/cm in single myocytes stained with a Ca(++)-sensitive or voltage-sensitive dye. Shocks caused a reversible period of depolarization, elevated cytosolic Ca++, and refractoriness. Intracellular Ca++ elevation had two temporal phases: first, a Ca++ spike with morphology independent of shock intensity; and second, a prolonged Ca++ elevation with a shock-intensity-dependent magnitude and duration, and with greatest Ca++ elevation at the poles of the cell adjacent to the electrodes. The prolonged elevation (second phase) was initiated earlier at the anode-facing pole of the cell than at the cathode-facing pole. These results suggest that postshock Ca++ entry consists of two parts: early normal entry through excitation channels plus a prolonged elevation which may be related to cellular damage.

References

Jul 1, 1976·IEEE Transactions on Bio-medical Engineering·M Klee, R Plonsey
Nov 1, 1991·Pacing and Clinical Electrophysiology : PACE·O Tovar, L Tung
Feb 1, 1991·Journal of Neuroscience Methods·N Lasser-RossW N Ross
May 1, 1990·Circulation Research·S YabeR E Ideker
May 1, 1990·IEEE Transactions on Bio-medical Engineering·V Krauthamer
Jul 1, 1987·The American Journal of Physiology·C A JonesJ K Brown
Jul 1, 1984·The American Journal of Physiology·D P Jones
Mar 1, 1980·Critical Care Medicine·J L Jones, R E Jones
May 1, 1995·Journal of Molecular and Cellular Cardiology·S B Knisley, A O Grant
Aug 1, 1993·Circulation·S Ballin, C Louis
Jul 1, 1963·Circulation·A M RUDOLPHJ M LEVY
Mar 25, 2005·The Journal of Organic Chemistry·Max J CryleJames J De Voss

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Citations

Sep 29, 2011·Intensive Care Medicine·Min-Shan TsaiWen-Jone Chen
Feb 22, 2001·Medical Engineering & Physics·B B BeardI A Chang
Nov 1, 2008·Critical Care Medicine·Giuseppe RistagnoMax Harry Weil
Oct 22, 2008·Critical Care Medicine·Min-Shan TsaiMax Harry Weil
Jun 26, 2012·American Journal of Physiology. Heart and Circulatory Physiology·Yves T WangYuanna Cheng
Sep 1, 2011·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Brittany Sowell, Vladimir G Fast
Oct 16, 2009·Biomaterials·Melissa S Ravenscroft-ChangJames J Hickman
Mar 26, 2008·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Vadim V FedorovIgor R Efimov
Jan 1, 2007·Drug Discovery Today. Technologies·Victor Krauthamer
Dec 17, 2003·Pacing and Clinical Electrophysiology : PACE·Yoshio YamanouchiPatrick J Tchou
Nov 8, 2008·IEEE Transactions on Bio-medical Engineering·Pedro Xavier de OliveiraJosé Wilson Magalhães Bassani
Jul 7, 2016·Pacing and Clinical Electrophysiology : PACE·Takeshi KodaniTohru Masuyama
Apr 6, 2002·Circulation Research·Vladimir G Fast, Eric R Cheek
Oct 31, 2000·Circulation Research·A Al-KhadraI R Efimov
May 25, 2004·Circulation Research·Vladimir G FastRaymond E Ideker
Jan 29, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Hanne Gissel
Jul 28, 2020·BMC Bioinformatics·Marcelo Zoccoler, Pedro X de Oliveira
Aug 17, 2005·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Vladimir P Nikolski, Igor R Efimov
May 31, 2018·Medical & Biological Engineering & Computing·José Américo Nabuco Leva Ferreira de FreitasPedro Xavier de Oliveira
Apr 29, 2003·Journal of Cardiovascular Electrophysiology·Takashi AshiharaMakoto Ito
Oct 12, 2020·Experimental Cell Research·Alberto Luis Ramírez HurtadoJesús Rodríguez González
Dec 31, 2016·Computers in Biology and Medicine·Jair Trapé GoulartJosé Wilson Magalhães Bassani

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