Calcium dynamics in dendritic spines and spine motility

Biophysical Journal
D HolcmanE Korkotian

Abstract

A dendritic spine is an intracellular compartment in synapses of central neurons. The role of the fast twitching of spines, brought about by a transient rise of internal calcium concentration above that of the parent dendrite, has been hitherto unclear. We propose an explanation of the cause and effect of the twitching and its role in the functioning of the spine as a fast calcium compartment. Our molecular model postulates that rapid spine motility is due to the concerted contraction of calcium-binding proteins. The contraction induces a stream of cytoplasmic fluid in the direction of the dendritic shaft, thus speeding up the time course of spine calcium dynamics, relative to pure diffusion. Simulations indicate that chemical reaction rate theory at the molecular level can explain spine motility. They reveal two time periods in calcium dynamics, as measured recently by other researchers. It appears that rapid motility in dendritic spines increases the efficiency of calcium conduction to the dendrite and speeds up the emptying of the spine. This could play a major role in the induction of synaptic plasticity. A prediction of the model is that alteration of spine motility will modify the time course of calcium in the dendritic s...Continue Reading

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Citations

Feb 21, 2009·Journal of Computational Neuroscience·Hartmut Schmidt, Jens Eilers
Apr 12, 2005·Cell Calcium·D HolcmanM Segal
Jan 1, 2011·Journal of Mathematical Neuroscience·David Holcman, Zeev Schuss
Dec 4, 2009·PloS One·Georgios Kalantzis, Harel Z Shouval
Jan 15, 2014·Antioxidants & Redox Signaling·Andrea C Paula-LimaCecilia Hidalgo
Feb 8, 2011·Mathematical Biosciences·M Dur-e-AhmadAsiya Gul
Nov 19, 2004·The European Journal of Neuroscience·Eduard KorkotianMenahem Segal
Jul 21, 2011·The European Journal of Neuroscience·Fidel SantamariaGeorge J Augustine
Oct 16, 2015·Nature Reviews. Neuroscience·David Holcman, Rafael Yuste
Feb 16, 2010·Cell Calcium·Jens Christian BrasenMaurice B Hallett
Apr 20, 2005·The Journal of Chemical Physics·D Holcman, Z Schuss
Oct 13, 2007·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·A BiessD Holcman
Jun 5, 2019·PLoS Biology·Kanishka BasnayakeDavid Holcman
Jul 22, 2019·The Journal of General Physiology·Miriam BellPadmini Rangamani
Aug 14, 2019·Scientific Reports·Andrea CugnoPadmini Rangamani
Apr 26, 2018·Physical Review Letters·Tal Agranov, Baruch Meerson
Dec 5, 2020·Journal of Biological Dynamics·Morteza RouhaniSharon M Crook
Oct 26, 2005·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·David HolcmanZeev Schuss

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