Calcium dynamics integrated into signalling pathways that influence vertebrate axial patterning

Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
Christina M FreisingerDiane C Slusarski

Abstract

Many aspects of animal development including fertilization as well as organ formation and function are dependent upon the dynamic release of calcium (Ca(2+)) ions. Although the controlled release and/or accumulation of Ca(2+) ions has been extensively studied, how the release dynamics produce a specific biological output in embryonic development is less clear. We will briefly summarize Ca(2+) sources, highlight data on endogenous Ca(2+) release in vertebrate embryos relevant to body plan formation and cell movement, and integrate pharmacological and molecular-genetic studies to lend insight into the signalling pathways involved. Finally, based on in vivo imaging in zebrafish genetic mutants, we will put forward the model that distinct Ca(2+) release dynamics lead to antagonism of the developmentally important Wnt/beta-catenin signalling pathway, while sustained Ca(2+) release modulates cell polarization or directed migration.

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Citations

Jan 15, 2008·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Michael Whitaker, Jim Smith
Feb 12, 2008·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Michael Whitaker
Oct 12, 2012·PLoS Biology·Shu-Yu WuLilianna Solnica-Krezel
Jul 16, 2010·PLoS Genetics·Christina M FreisingerDiane C Slusarski
Jul 28, 2010·The Journal of Cell Biology·Shengda LinDiane C Slusarski
Mar 6, 2016·Cell Calcium·Michelle K TuLaura N Borodinsky
Jul 24, 2012·Drug Discovery Today·Alexey Koval, Vladimir L Katanaev
Oct 4, 2015·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Henrique ChengKevin M Kleinow
May 4, 2010·Evolution & Development·Aurélie ComteMarc Robinson-Rechavi
Jun 22, 2010·Journal of Cellular and Molecular Medicine·Lorna S JohnstoneMarie A Dziadek
Sep 23, 2010·Developmental Biology·Igor SchneiderDiane C Slusarski
Jan 31, 2017·PeerJ·Yusuke TsuruwakaTomohisa Ogawa
Nov 30, 2018·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Ziqing LiShuying Yang
Oct 18, 2012·Physiological Reviews·Albrecht SchwabChristian Stock

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