Calcium dyshomeostasis in beta-amyloid and tau-bearing skeletal myotubes

The Journal of Biological Chemistry
Rial A ChristensenHenry W Querfurth

Abstract

The relative scarcity of inclusion-affected muscle cells or markers of cell death in inclusion body myositis (IBM) is in distinction to the specific and early intracellular deposition of several Alzheimer's Disease (AD)-related proteins. The current study examined the possible correlation between myotube beta-amyloid and/or Tau accumulations and a widespread mishandling of intracellular muscle calcium concentration that could potentially account for the unrelenting weakness in affected patients. Cultured myogenic cells (C(2)C(12)) expressed beta-amyloid-42 (Abeta(42)) and fetal Tau peptides, as human transgenes encoded by herpes simplex virus, either individually or concurrently. Co-expression of Abeta(42) in C(2)C(12) myotubes resulted in hyperphosphorylation of Tau protein that was not observed when Tau was expressed alone. Resting calcium concentration and agonist-induced RyR-mediated Ca(2+) release were examined using calcium-specific microelectrodes and Fluo-4 epifluorescence, respectively. Co-expression of Abeta(42) and Tau cooperatively elevated basal levels of myoplasmic-free calcium, an effect that was accompanied by depolarization of the plasma membrane. Sarcoplasmic reticulum (SR) calcium release, induced by KCl depo...Continue Reading

References

Jan 1, 1977·Physiological Reviews·M Endo
May 1, 1992·Journal of Neurochemistry·K KanemaruY Ihara
Jun 1, 1989·Neuron·G LeeK S Kosik
Nov 1, 1987·Journal of Cellular Physiology·S T IannacconeN Sperelakis
Jul 1, 1983·Biophysical Journal·J R LópezS Vergara
Aug 25, 1995·The Journal of Biological Chemistry·M YanoN Ikemoto
May 8, 1995·Biochimica Et Biophysica Acta·W MelzerH C Lüttgau
Jan 13, 1995·The Journal of Biological Chemistry·M Morishima-KawashimaY Ihara
Dec 15, 1994·Annals of the New York Academy of Sciences·R A NixonM Beermann
Nov 23, 1994·Molecular and Cellular Biochemistry·N ArispeE Rojas
Jan 1, 1994·Annual Review of Physiology·M F Schneider
Apr 19, 1994·Biochemistry·H W Querfurth, D J Selkoe
Sep 24, 1993·Annals of the New York Academy of Sciences·J T JarrettP T Lansbury
Aug 16, 1993·Biochemical and Biophysical Research Communications·H HartmannW E Müller
Jan 7, 1993·Nature·T V Bliss, G L Collingridge
Sep 1, 1996·Journal of Neurochemistry·Y GuY Ihara
Aug 1, 1997·The Journal of Biological Chemistry·M Hong, V M Lee
Jan 1, 1997·Molecular and Cellular Neurosciences·A FerreiraK S Kosik
Nov 20, 1997·The Journal of Biological Chemistry·D H MacLennanN M Green
May 30, 1998·Proceedings of the National Academy of Sciences of the United States of America·M P LambertW L Klein
Aug 5, 1998·Journal of Neuropathology and Experimental Neurology·N MurakamiY Ihara
Jan 12, 1999·Muscle & Nerve·S I NagaoT Tsuda
Jan 7, 2000·The American Journal of Pathology·G K GourasN R Relkin
Feb 1, 2000·European Archives of Psychiatry and Clinical Neuroscience·T Hartmann
Jun 28, 2000·Biochemistry·G G RodneyS L Hamilton
Mar 29, 2001·Physiological Reviews·D J Selkoe

❮ Previous
Next ❯

Citations

Apr 13, 2011·Proceedings of the National Academy of Sciences of the United States of America·José Miguel EltitJosé R Lopez
Jul 23, 2009·BMJ : British Medical Journal·Steven A Greenberg
Dec 10, 2013·European Journal of Pharmacology·Shreaya Chakroborty, Grace E Stutzmann
May 17, 2005·The International Journal of Biochemistry & Cell Biology·Paola CostelliFrancesco M Baccino
Jun 16, 2009·Journal of Neuropathology and Experimental Neurology·Sébastien PerreaultNicole Leclerc
Nov 21, 2007·Journal of Neurochemistry·José R LopezAlexander Shtifman
Dec 26, 2008·Neurobiology of Aging·Alexander ShtifmanHenry W Querfurth
Aug 18, 2009·Neurobiology of Aging·Alexander ShtifmanJin Xu
Sep 13, 2005·Current Opinion in Neurology·Anders Oldfors, Christopher Lindberg
Aug 31, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Charbel E-H MoussaHenry W Querfurth
Sep 30, 2008·The Journal of Biological Chemistry·Ramona BravoXavier Fernàndez-Busquets
Mar 23, 2017·Molecular Neurodegeneration·Michal Arbel-OrnathBrian J Bacskai
Jun 14, 2005·Neurobiology of Aging·Michael C SugarmanFrank M LaFerla

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alzheimer's Disease: APP

Amyloid precursor protein (APP) proteolysis is critical for the development of Alzheimer's disease, a neurodegenerative disease associated with accumulation of amyloid plaques in the brain. Here is the latest research on APP and Alzheimer's disease.

ASBMB Publications

The American Society for Biochemistry and Molecular Biology (ASBMB) includes the Journal of Biological Chemistry, Molecular & Cellular Proteomics, and the Journal of Lipid Research. Discover the latest research from ASBMB here.

Alzheimer's Disease: Tau & TDP-43

Alzheimer's disease is a neurodegenerative disease. This feed focuses on the underlying role of tau proteins and TAR DNA-binding protein 43, as well as other genetic factors, in Alzheimer's disease.

Alzheimer's Disease: Amyloid Beta

Alzheimer's disease is a neurodegenerative disease associated with the accumulation of amyloid plaques in the brain; these plaques are comprised of amyloid beta deposits. Here is the latest research in this field.

Related Papers

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
Charbel E-H MoussaHenry W Querfurth
The New England Journal of Medicine
Monte S Willis, Cam Patterson
© 2021 Meta ULC. All rights reserved