Calcium entry attenuates adenylyl cyclase activity. A possible mechanism for calcium-induced catecholamine resistance

Chest
W B AbernethyG P Zaloga

Abstract

In experimental animals, coadministration of calcium (Ca) salts with beta-adrenergic receptor agonists reduces the increased blood pressure and cyclic AMP (cAMP) produced by beta-adrenergic receptor agonists alone. In patients, coadministration of these drugs reduces the increased cardiac output and blood glucose produced by selective administration of beta-adrenergic agonists. The mechanism by which Ca might produce catecholamine resistance remains unclear. Healthy volunteers donated venous blood from which lymphocytes were isolated. The cAMP production was measured by radioimmunoassay under control conditions and after incubation with epinephrine or colforsin (forskolin) in the presence and absence of inhibitors. Epinephrine and colforsin produced concentration-dependent increases in cAMP production. Extracellular Ca concentration over the range from 0 to 8 mM did not inhibit basal cAMP production or that stimulated by either colforsin or epinephrine. The calcium channel agonist Bay K 8644 (50 microM) combined with normal extracellular Ca concentration significantly attenuated colforsin-induced increases in cAMP production. When barium was substituted for Ca in the extracellular fluid, the cAMP response to colforsin was resto...Continue Reading

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Citations

Feb 26, 2009·Veterinary Anaesthesia and Analgesia·Stijn SchauvliegeFrank Gasthuys
Dec 31, 1997·Journal of Cardiothoracic and Vascular Anesthesia·R Prielipp, J Butterworth
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