Calcium flickers steer cell migration.

Nature
Chaoliang WeiHeping Cheng

Abstract

Directional movement is a property common to all cell types during development and is critical to tissue remodelling and regeneration after damage. In migrating cells, calcium has a multifunctional role in directional sensing, cytoskeleton redistribution, traction force generation, and relocation of focal adhesions. Here we visualize high-calcium microdomains ('calcium flickers') and their patterned activation in migrating human embryonic lung fibroblasts. Calcium flicker activity is dually coupled to membrane tension (by means of TRPM7, a stretch-activated Ca(2+)-permeant channel of the transient receptor potential superfamily) and chemoattractant signal transduction (by means of type 2 inositol-1,4,5-trisphosphate receptors). Interestingly, calcium flickers are most active at the leading lamella of migrating cells, displaying a 4:1 front-to-rear polarization opposite to the global calcium gradient. When exposed to a platelet-derived growth factor gradient perpendicular to cell movement, asymmetric calcium flicker activity develops across the lamella and promotes the turning of migrating fibroblasts. These findings show how the exquisite spatiotemporal organization of calcium microdomains can orchestrate complex cellular proce...Continue Reading

References

Jun 28, 1996·Journal of Toxicology and Environmental Health·R L KodellD W Gaylor
Oct 28, 1998·Physiological Reviews·E J Pettit, F S Fay
Dec 3, 1999·Science·R C RobinsonS Choe
Dec 28, 1999·Science·A R Horwitz, J T Parsons
Feb 5, 2000·Current Biology : CB·D ThomasM D Bootman
May 2, 2002·Proceedings of the National Academy of Sciences of the United States of America·Hui ZouJoshua J Singer
Jun 25, 2002·Nature Cell Biology·Orion D WeinerHenry R Bourne
Jul 5, 2003·Physiological Reviews·Sabine Werner, Richard Grose
Jul 31, 2003·The Journal of Biological Chemistry·Leo S PriceJohn G Collard
Dec 6, 2003·Science·Anne J RidleyAlan Rick Horwitz
Jun 11, 2004·Annual Review of Biochemistry·Randen L PattersonSolomon H Snyder
Jun 16, 2004·Development·Paul Martin, Susan M Parkhurst
Sep 16, 2004·Nature Reviews. Molecular Cell Biology·Peter J M Van Haastert, Peter N Devreotes
Sep 28, 2004·Nature Cell Biology·Santos J FrancoAnna Huttenlocher
Jan 27, 2005·Proceedings of the National Academy of Sciences of the United States of America·Shi ShuEdward D Korn
Aug 11, 2006·Journal of Cell Science·Thomas P StosselJohn H Hartwig
Sep 1, 2006·American Journal of Physiology. Cell Physiology·Tomohiro NumataYasunobu Okada
Jan 24, 2007·Physiological Reviews·Bernd NiliusJohn A Peters
May 31, 2007·The Journal of Cell Biology·Peter J M van HaastertArjan Kortholt
Oct 4, 2007·Proceedings of the National Academy of Sciences of the United States of America·John H Evans, Joseph J Falke
Oct 17, 2008·Physiological Reviews·Heping Cheng, W J Lederer

❮ Previous
Next ❯

Citations

Dec 17, 2009·Cellular and Molecular Life Sciences : CMLS·Jeroen MiddelbeekFrank N van Leeuwen
Apr 15, 2010·Journal of Clinical Immunology·Matthew F Krummel, Michael D Cahalan
Apr 13, 2010·Biochemical Pharmacology·Javier MilaraJulio Cortijo
Jan 24, 2014·Chemistry and Physics of Lipids·Joseph J Falke, Brian P Ziemba
Oct 5, 2011·ACS Chemical Biology·Brenda N Goguen, Barbara Imperiali
May 10, 2011·Acta Pharmacologica Sinica·Christine You-jin Bae, Hong-shuo Sun
Sep 28, 2010·Cellular & Molecular Immunology·Aiko-Konno ShirakawaJoshua M Farber
May 18, 2010·Nature Immunology·Richard A ColvinAndrew D Luster
Oct 24, 2009·Nature Reviews. Cancer·Maria Mancini, Alex Toker
Jul 16, 2009·Nature Reviews. Molecular Cell Biology·Ryan J PetrieKenneth M Yamada
Aug 3, 2010·Proceedings of the National Academy of Sciences of the United States of America·Neil C ChiDidier Y R Stainier
Mar 4, 2011·Proceedings of the National Academy of Sciences of the United States of America·Qian XieGeorge F Vande Woude
May 10, 2012·Proceedings of the National Academy of Sciences of the United States of America·Jacinta C Conrad
Jan 9, 2013·Proceedings of the National Academy of Sciences of the United States of America·Min WuPietro De Camilli
Nov 3, 2010·The Journal of Biological Chemistry·Hiroki Akiyama, Hiroyuki Kamiguchi
Oct 20, 2010·The Journal of Biological Chemistry·Toshifumi FukudaShigeru Yanagi
Jun 11, 2011·The Journal of Biological Chemistry·Qi MaHeping Cheng
Jul 24, 2012·The Journal of Biological Chemistry·Gregory R MonteithSarah J Roberts-Thomson
Aug 14, 2013·The Journal of Cell Biology·Nuno SaraivaGeoffrey L Smith
Jun 4, 2010·Molecular Biology of the Cell·Zhong-Hua LiAnne R Bresnick
Aug 27, 2011·Science Signaling·Maria HatziapostolouPhilip N Tsichlis
Aug 13, 2010·American Journal of Physiology. Cell Physiology·Sean P ParsonsJan D Huizinga
Dec 12, 2012·American Journal of Respiratory Cell and Molecular Biology·Hiromichi AsoYoshinori Hasegawa
Apr 19, 2013·Journal of Biomedical Science·Yih-Fung ChenMeng-Ru Shen
Nov 20, 2012·Journal of Neuroinflammation·Tamjeed A SiddiquiLyanne C Schlichter
Aug 4, 2012·Journal of Leukocyte Biology·Jinmin LeeDavid Holowka
Sep 21, 2012·Journal of Cell Science·Marta MartinsMatilda Katan
Jun 30, 2011·PLoS Biology·Sébastien TauzinPatrick Legembre
Jun 14, 2012·PLoS Computational Biology·Sten RüdigerJian-Wei Shuai
Jun 21, 2011·PloS One·Taeseok Daniel YangKyoung J Lee
Jan 4, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Patrick C KersteinTimothy M Gomez

❮ Previous
Next ❯

Related Concepts

Related Feeds

Actin, Myosin & Cell Movement

Contractile forces generated by the actin-myosin cytoskeleton are critical for morphogenesis, but the cellular and molecular mechanisms of contraction have been elusive for many cell shape changes and movements. Here is the latest research on the roles of actin and myosin in cell movement.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Calcium & Bioenergetics

Bioenergetic processes, including cellular respiration and photosynthesis, concern the transformation of energy by cells. Here is the latest research on the role of calcium in bioenergetics.