Calcium Homeostasis and Ionic Mechanisms in Pulmonary Fibroblasts

American Journal of Respiratory Cell and Molecular Biology
Luke J JanssenKjetil Ask

Abstract

Fibroblasts are key cellular mediators of many chronic interstitial lung diseases, including idiopathic pulmonary fibrosis, scleroderma, sarcoidosis, drug-induced interstitial lung disease, and interstitial lung disease in connective tissue disease. A great deal of effort has been expended to understand the signaling mechanisms underlying the various cellular functions of fibroblasts. Recently, it has been shown that Ca(2+) oscillations play a central role in the regulation of gene expression in human pulmonary fibroblasts. However, the mechanisms whereby cytosolic [Ca(2+)] are regulated and [Ca(2+)] oscillations transduced are both poorly understood. In this review, we present the general concepts of [Ca(2+)] homeostasis, of ionic mechanisms responsible for various Ca(2+) fluxes, and of regulation of gene expression by [Ca(2+)]. In each case, we then also summarize the original findings that pertain specifically to pulmonary fibroblasts. From these data, we propose an overall signaling cascade by which excitation of the fibroblasts triggers pulsatile release of internally sequestered Ca(2+), which, in turn, activates membrane conductances, including voltage-dependent Ca(2+) influx pathways. Collectively, these events produce r...Continue Reading

References

Jan 1, 1987·Annual Review of Biophysics and Biophysical Chemistry·R W TsienR L Rosenberg
May 1, 1988·Pflügers Archiv : European journal of physiology·A PeresG Mostacciuolo
Feb 1, 1989·Experimental Cell Research·A PeresR Zippel
Jul 1, 1987·Journal of Cellular Physiology·M CasparM Thelestam
May 1, 1995·The American Journal of Physiology·R Sitsapesan, A J Williams
Jun 1, 1994·The Journal of Investigative Dermatology·J LohiJ Keski-Oja
Jan 28, 1993·Nature·M J Berridge
Dec 22, 1995·The Journal of Biological Chemistry·V J Thannickal, B L Fanburg
Nov 1, 1995·Trends in Pharmacological Sciences·R SitsapesanA J Williams
Mar 1, 1997·The Journal of Physiology·M J Berridge
Nov 14, 1997·Physiological Reviews·H C Lee
Feb 14, 1998·The Journal of Biological Chemistry·C M ZimmermanL S Mathews
Apr 16, 1998·Biochemical and Biophysical Research Communications·T KatoK Naruse
May 1, 1998·American Journal of Respiratory and Critical Care Medicine·A L Katzenstein, J L Myers
Oct 28, 1998·Nature·M J BerridgeP Lipp
Jan 19, 1999·Annual Review of Cell and Developmental Biology·R ChapmanP Walter
Jun 22, 1999·Cellular Signalling·A H Guse
Nov 30, 1999·Irish Journal of Medical Science·K D Thornbury
Aug 23, 2000·Pflügers Archiv : European journal of physiology·K E PembertonS V Jones
Mar 22, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·O EickelbergM Roth
Mar 30, 2001·The Journal of Biological Chemistry·A S StevensonM T Nelson
Apr 9, 2001·The Journal of Biological Chemistry·C HuangX Shi
Jun 20, 2001·Nature Reviews. Molecular Cell Biology·M J BerridgeM D Bootman
Jan 16, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Hidefumi InohKeiji Naruse

❮ Previous
Next ❯

Citations

Aug 1, 2015·PloS One·Alejandro Guzmán-SilvaRoberto Berra-Romani
Jan 29, 2017·American Journal of Physiology. Lung Cellular and Molecular Physiology·Subhendu MukherjeeLuke J Janssen
Feb 3, 2018·American Journal of Respiratory Cell and Molecular Biology·Mozibur RahmanLuke J Janssen
Jul 10, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Momin MohisGracious R Ross
Sep 6, 2019·American Journal of Respiratory Cell and Molecular Biology·Anne M ScruggsSteven K Huang
Oct 18, 2019·American Journal of Respiratory Cell and Molecular Biology·Rachel G Scheraga, Mitchell A Olman
Nov 24, 2019·British Journal of Pharmacology·Katy M Roach, Peter Bradding
Feb 9, 2020·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Samuel J GhilardiAllyson E Sgro
Jun 29, 2018·Frontiers in Medicine·Ioanna NinouVassilis Aidinis
May 4, 2017·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Dong Un LeeJeong Hee Hong
Aug 6, 2019·European Journal of Clinical Investigation·Yu-Hsun KaoYi-Jen Chen
Oct 28, 2019·International Journal of Molecular Sciences·Alessandro Alaimo, Josep Rubert
Feb 7, 2016·American Journal of Physiology. Lung Cellular and Molecular Physiology·Mozibur RahmanLuke J Janssen
Jul 12, 2020·Journal of Cell Science·Pardis PakshirBoris Hinz
Nov 11, 2020·Therapeutic Advances in Respiratory Disease·Yunguan WangAnil G Jegga
Nov 3, 2020·Cardiovascular Research·Nikolaos G Frangogiannis
Jan 24, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Yuefang ZhouAlan Shiels
Jul 30, 2018·Molecular Aspects of Medicine·Nikolaos G Frangogiannis

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

American Thoracic Association Journals

Discover the latest respiratory research published by the journals from the American Thoracic Society.

Calcium & Bioenergetics

Bioenergetic processes, including cellular respiration and photosynthesis, concern the transformation of energy by cells. Here is the latest research on the role of calcium in bioenergetics.