Calcium imaging of sleep-wake related neuronal activity in the dorsal pons

Nature Communications
Julia CoxYang Dan

Abstract

The dorsal pons has long been implicated in the generation of rapid eye movement (REM) sleep, but the underlying circuit mechanisms remain poorly understood. Using cell-type-specific microendoscopic Ca(2+) imaging in and near the laterodorsal tegmental nucleus, we found that many glutamatergic neurons are maximally active during REM sleep (REM-max), while the majority of GABAergic neurons are maximally active during wakefulness (wake-max). Furthermore, the activity of glutamatergic neurons exhibits a medio-lateral spatial gradient, with medially located neurons more selectively active during REM sleep.

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Software Mentioned

ScanImage
nVista HD
MATLAB
GAD2
nVista Viewer
VGLUT2
MathWorks

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