Calcium in Brugada Syndrome: Questions for Future Research

Frontiers in Physiology
Michelle M MonaskyLuigi Anastasia

Abstract

The Brugada syndrome (BrS) is characterized by coved-type ST-segment elevation in the right precordial leads on the electrocardiogram (ECG) and increased risk of sudden cardiac death (SCD). While it is an inheritable disease, determining the true prevalence is a challenge, since patients may report no known family history of the syndrome, present with a normal spontaneous ECG pattern at the time of examination, and test negative for all known BrS-causative genes. In fact, SCD is often the first indication that a person is affected by the syndrome. Men are more likely to be symptomatic than women. Abnormal, low-voltage, fractionated electrograms have been found in the epicardium of the right ventricular outflow tract (RVOT). Ablation of this area abolishes the abnormal electrograms and helps to prevent arrhythmic recurrences. BrS patients are more likely to experience ventricular tachycardia/fibrillation (VT/VF) during fever or during an increase in vagal tone. Isoproterenol helps to reverse the ECG BrS phenotype. In this review, we discuss roles of calcium in various conditions that are relevant to BrS, such as changes in temperature, heart rate, and vagal tone, and the effects of gender and isoproterenol on calcium handling. S...Continue Reading

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Citations

Sep 12, 2019·Panminerva Medica·Milan M MarinkovićTatjana S Potpara
Mar 4, 2020·International Journal of Molecular Sciences·Michelle M MonaskyCarlo Pappone
Jul 12, 2019·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Michelle M MonaskyCarlo Pappone
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Nov 9, 2019·International Journal of Molecular Sciences·Michelle M MonaskyCarlo Pappone
Aug 15, 2020·Pflügers Archiv : European journal of physiology·Chih-Min LiuYi-Jen Chen
Jan 7, 2021·Pflügers Archiv : European journal of physiology·Shanna HamiltonDmitry Terentyev
Mar 4, 2021·European Heart Journal Supplements : Journal of the European Society of Cardiology·Carlo PapponeMichelle M Monasky
Oct 17, 2020·General Hospital Psychiatry·Anuj RastogiJohn Lally
May 11, 2021·Frontiers in Cardiovascular Medicine·Michelle M MonaskyCarlo Pappone
Aug 3, 2021·Cardiology Research and Practice·Mohammad Hossein NikooSeyed Taghi Heydari
Aug 28, 2021·Nutrients·Sara D'ImperioCarlo Pappone

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