PMID: 6409423Jun 1, 1983Paper

Calcium-independent adhesion of extra-embryonic endoderm cells from the early chick blastoderm is inhibited by the blastoderm beta-D-galactoside-binding lectin and by beta-galactosidase

Cell Differentiation
N Milos, S E Zalik

Abstract

Extra-embryonic endoderm cells from gastrulating chick embryos possess Ca2+-dependent and Ca2+-independent adhesive mechanisms. These cells also contain an endogenous beta-D-galactoside-binding lectin and cell surface receptors bearing galactose groups. The endogenous lectin inhibits cellular adhesion. To test whether the adhesive interactions involving lectin and galactose molecules are part of the Ca2+-independent or Ca2+-dependent adhesive mechanism, dissociated cells which were preincubated in beta-galactosidase were allowed to aggregate in the presence and absence of Ca2+ ions. Significant decreases in adhesion were observed in both cases. Cells were also allowed to aggregate in the presence and absence of Ca2+ ions when blastoderm lectin was present in the medium. Adhesion was decreased in both cases. The results suggest that cell surface galactose groups and the beta-D-galactoside-binding lectin are involved in Ca2+-independent adhesion.

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Citations

Dec 17, 2008·Parasitology·M J G JohnstonD M McKay
Oct 23, 2013·Seminars in Diagnostic Pathology·Zhaohai YangDavid S Klimstra
Apr 1, 1985·The Journal of Experimental Zoology·A Fausto-SterlingP L Rosenblatt
Sep 1, 1987·The Journal of Experimental Zoology·K D AtnipD J Donaldson
May 1, 1990·Roux's Archives of Developmental Biology : the Official Organ of the EDBO·Esmond J SandersIrene M Ledsham
Mar 1, 1986·Experimental Cell Research·B Obrink
May 1, 1988·Journal of Cellular Biochemistry·R Lotan, A Raz

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