Calcium-independent modulation of cyclic GMP and activation of guanylate cyclase by nitrosamines

Science
F R Derubertis, P A Craven

Abstract

Nitrosamines markedly increase concentrations of guanosine 3', 5' - monophosphate (cyclic GMP) in several tissues from the rat and in human colonic mucosa. These agents are effective in the absence of extracellular calcium and enhance guanylate cyclase activity in tissue homogenates. Stimulation of cyclic GMP was greatest in liver, where the carcinogenic activity of nitrosamines is also most pronounced.

Citations

Jan 1, 1993·Medicinal Research Reviews·Y NomuraY Tokumitsu
Jul 18, 1977·Naunyn-Schmiedeberg's Archives of Pharmacology·K SchultzG Schultz
Jul 27, 1979·Biochemical and Biophysical Research Communications·F R Derubertis, P A Craven
Oct 9, 1991·Biochemical Pharmacology·J G Elferink, B M de Koster
Apr 23, 1979·Life Sciences·M K HaddoxN D Goldberg
Jan 1, 1980·Toxicon : Official Journal of the International Society on Toxinology·D C LehotayK D Miller
Jan 1, 1978·Mutation Research·A KleinhofsR A Nilan
Sep 1, 1982·Toxicology Letters·T KobayashiS Nagasawa
Oct 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·C K Mittal, F Murad
Aug 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·W P ArnoldF Murad
Feb 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·A J ClaflinG S Levey
May 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·L J IgnarroM S Wolin
Dec 22, 1999·Journal of Cardiovascular Pharmacology·L J IgnarroC Napoli
Jul 1, 1986·The Journal of Clinical Investigation·F Murad
Oct 16, 1999·Anesthesiology·W SteudelWarren M Zapol
Nov 1, 1979·Biochimica Et Biophysica Acta·W A SpruillH S Earp
Dec 22, 2009·Angewandte Chemie·Marie M MelzerTimothy H Warren
Mar 16, 1983·Biochemical and Biophysical Research Communications·M H Rochat, D L Vesely
Dec 1, 1987·Experimental and Molecular Pathology·V V TertovV N Smirnov
Dec 1, 1977·Chemico-biological Interactions·M J Tisdale, B J Phillips
Oct 1, 1984·Medicinal Research Reviews·M L Tjörnhammar, T Bartfai
Aug 22, 1977·Biochemical and Biophysical Research Communications·D L VeselyG S Levey
Sep 30, 1982·Biochemical and Biophysical Research Communications·R GerzerD L Garbers
Jan 24, 1977·Biochemical and Biophysical Research Communications·D L Vesely, G S Levey
Nov 30, 1981·Biochemical and Biophysical Research Communications·P J LadA A White
Jan 30, 1977·Archives of Biochemistry and Biophysics·T V ZenserB B Davis
Sep 12, 1979·Biochemical and Biophysical Research Communications·S NagaoY Nozawa
Jul 1, 1994·American Heart Journal·N J Mangione, S P Glasser
Apr 28, 1978·Biochemical and Biophysical Research Communications·D L Vesely, G S Levey
Sep 21, 2016·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Eduardo Nava, Silvia Llorens
Oct 11, 2003·Circulation Research·Andrei L KleschyovThomas Münzel
May 1, 1981·Journal of Periodontal Research·C A HedinO Forsberg
Feb 9, 2019·Dalton Transactions : an International Journal of Inorganic Chemistry·Pai-Heng LiuWen-Feng Liaw
Jul 1, 1978·Bulletin of Environmental Contamination and Toxicology·D L Vesely, G S Levey
Jan 1, 1995·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·H Niknahad, P J O'Brien
Sep 1, 1984·The American Journal of Physiology·K Sato, F Sato

Related Concepts

Metazoa
Calcium
Taenia Coli
Enzyme Activation
Cyclic GMP
Guanylate Cyclase
Structure of Intestinal Gland
Structure of Cortex of Kidney
Liver
Lung

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