PMID: 737172Dec 19, 1978Paper

Calcium-induced aggregation and fusion of mixed phosphatidylcholine-phosphatidic acid vesicles as studied by 31P NMR

Biochimica Et Biophysica Acta
M KoterL L van Deenen

Abstract

1. The transbilayer distribution of the phospholipids in sonicated egg phosphatidylcholine-phosphatidic acid vesicles and the interaction of Ca2+ with these vesicles was studied by 31P NMR. 2. Over a wide composition range the bilayer of these vesicles has a symmetrical phospholipid composition. 3. With ratios of Ca2+ to phosphatidic acid in the outer monolayer of the vesicles up to 0.3, Ca2+ induces vesicle aggregation. The extent of aggregation is increased by the Ca2+ concentration in the medium and the outer monolayer concentration of phosphatidic acid. The vesicle aggregation can be fully reversed by chelating Ca2+. 4. When the ratio exceeds 0.5 Ca2+ induces vesicle fusion. The fusion is maximal for vesicles containing both phosphatidylcholine and phosphatidic acid. The data suggest that Ca2+-induced lateral phase separations make the bilayer more susceptible to fusion.

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Citations

Oct 17, 2012·The Journal of Biological Chemistry·Minjung ChaeGeorge M Carman
Jan 22, 2013·The Journal of Biological Chemistry·Minjung Chae, George M Carman
Dec 1, 1993·Journal of Neurochemistry·R ShinghalS M Bajjalieh
Apr 14, 2009·Biochimica Et Biophysica Acta·Edgar Eduard Kooijman, Koert N J Burger
Oct 2, 1980·Biochimica Et Biophysica Acta·M J Liao, J H Prestegard
Aug 6, 1981·Biochimica Et Biophysica Acta·R EkerdtM Gratzl
Feb 28, 1980·Biochimica Et Biophysica Acta·S TokutomiS I Ohnishi
Jun 22, 1981·Biochimica Et Biophysica Acta·P SchlieperR Kaufmann
Dec 16, 1980·Biochemical and Biophysical Research Communications·G M Helmkamp
Jul 22, 2014·Progress in Neurobiology·Stephen D MerineyCameron B Gundersen
Jul 14, 1982·Biochimica Et Biophysica Acta·S Ohki
Dec 21, 1981·Biochimica Et Biophysica Acta·R Sundler, D Papahadjopoulos
Aug 19, 1980·Biochemistry·S E SchulleryT E Thompson
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Feb 3, 1995·The Journal of Biological Chemistry·S M Bajjalieh, R H Scheller
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Feb 6, 2007·The Journal of Biological Chemistry·Edgar E KooijmanBen de Kruijff
Sep 24, 2020·Journal of Lipid Research·Prabuddha DeyGeorge M Carman
Feb 4, 2021·Journal of Lipid Research·Prabuddha DeyGeorge M Carman
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Apr 8, 1993·Biochimica Et Biophysica Acta·P L GiesenW T Hermens

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