PMID: 8459099Mar 1, 1993Paper

Calcium induced calcium release is involved in the afterhyperpolarization in one class of guinea pig sympathetic neurone

Journal of the Autonomic Nervous System
P JoblingP Sah

Abstract

The mechanisms underlying two potassium conductances which are activated by Ca2+ influx during the action potential in sympathetic prevertebral neurones of guinea pigs have been investigated pharmacologically. One Ca-activated K+ conductance, which is present in all mammalian sympathetic postganglionic neurones, is maximal after the action potential and decays exponentially with a time constant of about 130 ms; this conductance was inhibited by apamin (50-100 nM) consistent with the involvement of SK channels. A second Ca-activated K+ conductance with much slower kinetics is present in a large subpopulation of coeliac neurones. This conductance was resistant to apamin but markedly inhibited by application of ryanodine (5-20 microM), suggesting that Ca2+ influx during the action potential triggers release of Ca2+ from intracellular stores which in turn activates a different class of K+ channel. Noradrenaline (100 microM) depressed the second K+ conductance selectively.

References

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Citations

Nov 1, 1994·Neuroscience·P Kostyuk, A Verkhratsky
Jul 22, 1998·Journal of the Autonomic Nervous System·K Kukuła, P J Szulczyk
Dec 23, 1998·Journal of the Autonomic Nervous System·D R IrelandE M McLachlan
Sep 6, 2000·Clinical and Experimental Pharmacology & Physiology·P Sah, P Davies
Apr 4, 2002·The Journal of General Physiology·Pratip Mitra, Malcolm M Slaughter
Apr 17, 2013·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·Leonhard LintaStefan Liebau
May 3, 2002·The Journal of Physiology·Damian J WallacePhilip D Marley
Jan 16, 2004·The Journal of Physiology·Sarah A LocknarRodney L Parsons
Jan 16, 2002·The Journal of Physiology·Fivos VogalisJohn B Furness
Jan 1, 1995·Clinical and Experimental Hypertension : CHE·E M McLachlan
Mar 26, 1999·Cell Calcium·A J Verkhratsky, O H Petersen
Sep 5, 2019·International Archives of Occupational and Environmental Health·Gabriele RotterAnne Berghöfer
Nov 24, 1999·Journal of Neurophysiology·P Jobling, I L Gibbins
Sep 6, 2001·Journal of Neurophysiology·R L AndersonI L Gibbins
May 16, 2001·Journal of Neurophysiology·F VogalisW A Kunze
Aug 22, 2020·American Journal of Physiology. Heart and Circulatory Physiology·Annika WinboJohanna M Montgomery

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