PMID: 9535115Apr 16, 1998Paper

Calcium inflow of hamster Merkel cells in response to hyposmotic stimulation indicate a stretch activated ion channel

Neuroscience Letters
M Tazaki, T Suzuki

Abstract

The aim of this study was to investigate the existence of the stretch activated ion channels in single Merkel cell using microfluorimetric techniques. Single Merkel cells were dissociated enzymatically from the touch domes in the cheek pouch mucosa of 4-8 week old golden hamsters. They were loaded with calcium (Ca2+) fluorescent indicator fura-2/AM. The increase in intracellular Ca2+ concentration ([Ca2+]i) of a single Merkel cell (quinacrine fluorescent cell) was induced by hyposmotic solution in normal Krebs solution, while it was not induced by Ca2+-free hyposmotic solution in Ca2+-free physiological solution. Gadolinium ion (10 microM) in normal Krebs solution partially blocked the increase in [Ca2+]i of Merkel cells induced by hyposmotic solution. Hence, this study revealed that stretch activated ion channels existed on the Merkel cell membrane.

Citations

Aug 14, 2012·Archives of Dermatological Research·Chenyu HuangRei Ogawa
Apr 17, 2008·Pflügers Archiv : European journal of physiology·Rebecca PiskorowskiEllen A Lumpkin
Jul 15, 2005·Journal of Neurophysiology·S J BensmaïaK O Johnson
May 6, 2008·PloS One·Henry HaeberleEllen A Lumpkin
Nov 10, 2009·PloS One·Nicholas BoulaisLaurent Misery
Jun 1, 2008·Chemosensory Perception·Henry Haeberle, Ellen A Lumpkin
Jul 16, 2015·Veterinary Dermatology·Gustavo A RamírezAntonio Espinosa-de-los-Monteros
Nov 14, 2002·Annual Review of Genetics·Glen G Ernstrom, Martin Chalfie
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Jul 24, 2014·Pflügers Archiv : European journal of physiology·Masashi NakataniEllen A Lumpkin
Jun 28, 2019·Frontiers in Cellular Neuroscience·Asuka HigashikawaYoshiyuki Shibukawa

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