Calcium ingestion suppresses appetite and produces acute overcompensation of energy intake independent of protein in healthy adults

The Journal of Nutrition
Javier T GonzalezEmma J Stevenson

Abstract

Prior evidence suggests that high-calcium intake influences postprandial appetite and insulinemia, possibly due to elevated incretins. In vitro and ex vivo models demonstrate that extracellular calcium and protein synergistically enhance secretion of incretins. This is yet to be shown in humans. This study was designed to assess energy intake compensation in response to protein and calcium ingestion. Twenty healthy adults (13 men; 7 women) completed 4 trials in a randomized, double-blind crossover design separated by ≥48 h. During the trials, each participant consumed a low-calcium and low-protein control preload [(CON); 4 g and 104 mg, respectively], a high-protein preload (PRO; 29 g), a high-calcium preload (CAL; 1170 mg), or a high-protein and high-calcium preload (PROCAL). Blood samples were collected at baseline and 15, 30, 45, and 60 min after preload ingestion to determine insulin and incretin hormone concentrations. Energy intake was assessed by a homogenous test meal 60 min after the preload. Visual analog scales were completed immediately before blood sampling to assess subjective appetite sensations. Relative to the CON, the PRO produced 100% (95% CI: 85%, 115%) energy compensation, whereas the CAL produced significa...Continue Reading

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Citations

Jun 22, 2016·The Journal of Endocrinology·E P S ConceiçãoP C Lisboa
Nov 1, 2018·European Journal of Sport Science·Lewis J JamesCarl J Hulston
May 16, 2018·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·K L StanhopeR M Krauss
Jul 12, 2020·European Journal of Applied Physiology·Javier T GonzalezLuc J C van Loon
Jul 1, 2021·Advances in Nutrition·Jonathan D WatkinsJavier T Gonzalez

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