Abstract
Prior evidence suggests that high-calcium intake influences postprandial appetite and insulinemia, possibly due to elevated incretins. In vitro and ex vivo models demonstrate that extracellular calcium and protein synergistically enhance secretion of incretins. This is yet to be shown in humans. This study was designed to assess energy intake compensation in response to protein and calcium ingestion. Twenty healthy adults (13 men; 7 women) completed 4 trials in a randomized, double-blind crossover design separated by ≥48 h. During the trials, each participant consumed a low-calcium and low-protein control preload [(CON); 4 g and 104 mg, respectively], a high-protein preload (PRO; 29 g), a high-calcium preload (CAL; 1170 mg), or a high-protein and high-calcium preload (PROCAL). Blood samples were collected at baseline and 15, 30, 45, and 60 min after preload ingestion to determine insulin and incretin hormone concentrations. Energy intake was assessed by a homogenous test meal 60 min after the preload. Visual analog scales were completed immediately before blood sampling to assess subjective appetite sensations. Relative to the CON, the PRO produced 100% (95% CI: 85%, 115%) energy compensation, whereas the CAL produced significa...Continue Reading
References
Jun 1, 1977·Gut·J BeharR D Smyth
Jan 1, 1985·Journal of Psychosomatic Research·A J Stunkard, S Messick
Mar 7, 2000·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·A FlintA Astrup
Apr 18, 2000·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Y SheininH S Cross
Apr 26, 2000·Proceedings of the National Academy of Sciences of the United States of America·A D ConigraveE M Brown
Oct 26, 2002·The American Journal of Clinical Nutrition·G Harvey AndersonThomas M S Wolever
Mar 9, 2007·The American Journal of Clinical Nutrition·Janne Kunchel LorenzenArne Astrup
Oct 12, 2007·Physiological Reviews·Jens Juul Holst
May 13, 2008·The American Journal of Clinical Nutrition·Nikolaj T GregersenArne Astrup
Jun 6, 2009·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·R ChristensenA Astrup
Feb 19, 2010·The American Journal of Clinical Nutrition·Tina AkhavanG Harvey Anderson
Feb 1, 2011·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Wendy Chan She Ping-Delfos, Mario Soares
May 20, 2011·Diabetes·Daniela LamersJuergen Eckel
Jun 3, 2011·Nutrition Reviews·Igho J OnakpoyaEdzard Ernst
Aug 16, 2011·Nutrition Research·Diane K Tidwell, Melinda W Valliant
Dec 6, 2011·The British Journal of Nutrition·Javier T Gonzalez, Emma J Stevenson
Apr 13, 2012·The Journal of Physiology·Oliver J MaceSonal Patel
Jun 1, 2012·Molecular Nutrition & Food Research·Shingo NakajimaHiroshi Hara
Jun 20, 2012·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·J T GonzalezE J Stevenson
Jan 24, 2013·The British Journal of Nutrition·Javier T GonzalezEmma J Stevenson
May 22, 2013·European Journal of Nutrition·Javier T Gonzalez, Emma J Stevenson
Jul 3, 2013·Nutrition Reviews·Eva Almiron-RoigAdam Drewnowski
Jul 23, 2013·The British Journal of Nutrition·Ulrike Trautvetter, Gerhard Jahreis
Jul 31, 2013·The Journal of Physiology·Josua JordiFrançois Verrey
Oct 17, 2013·Food Chemistry·Alice B Nongonierma, Richard J FitzGerald
Nov 8, 2013·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Javier T GonzalezEmma J Stevenson
Mar 14, 2014·The American Journal of Clinical Nutrition·Karina V SoerensenJanne K Lorenzen
Mar 20, 2014·European Journal of Clinical Nutrition·J T GonzalezE J Stevenson
Mar 29, 2014·The American Journal of Clinical Nutrition·Nerys M AstburyIan A Macdonald
Citations
Jun 25, 2016·Nutrients·Meghan A BrownPenny L S Rumbold
Jun 22, 2016·The Journal of Endocrinology·E P S ConceiçãoP C Lisboa
Nov 5, 2016·Appetite·Benjamin P GreenPenny L S Rumbold
Dec 1, 2017·The British Journal of Nutrition·Hélène ArguinVicky Drapeau
Jun 28, 2018·Experimental Physiology·Yung-Chih ChenJavier T Gonzalez
Nov 28, 2018·Nutrition Research Reviews·Anestis DougkasCarolyn D Summerbell
Nov 1, 2018·European Journal of Sport Science·Lewis J JamesCarl J Hulston
Sep 19, 2019·European Journal of Nutrition·Yung-Chih ChenJavier T Gonzalez
May 16, 2018·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·K L StanhopeR M Krauss
Jun 24, 2020·European Journal of Nutrition·Dean M AllertonEmma J Stevenson
Jul 12, 2020·European Journal of Applied Physiology·Javier T GonzalezLuc J C van Loon
Mar 12, 2021·The Journal of Nutrition·Akiho IgarashiTohru Hira
Jul 1, 2021·Advances in Nutrition·Jonathan D WatkinsJavier T Gonzalez